Rabbit polyclonal DDX5 antibody (A5296)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal DDX5 antibody (A5296)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal DDX5 antibody.

Alternative names:

Check alternative names for the antibody

Expand

p68 antibody, HLR1 antibody, G17P1 antibody, HUMP68 antibody
ATP dependent RNA helicase DDX5 antibody|DDX 5 antibody|Ddx5 antibody|DDX5_HUMAN antibody|DEAD (Asp Glu Ala Asp) box helicase 5 antibody|DEAD (Asp Glu Ala Asp) box polypeptide 5 antibody|DEAD box 5 antibody|DEAD box protein 5 antibody|DEAD/H (Asp Glu Ala Asp/His) box polypeptide 5 (RNA helicase, 68kD) antibody|G17P1 antibody|HELR antibody|HLR1 antibody|HUMP68 antibody|P68 antibody|p68 RNA helicase antibody|Probable ATP dependent RNA helicase DDX5 antibody|Probable ATP-dependent RNA helicase DDX5 antibody|RNA helicase p68 antibody|Anti-DDX5 antibody (ab21696)

SCBT cat No: sc-166167|sc-26045|sc-365164|sc-32858|

Name

Rabbit polyclonal DDX5 antibody

Catalogue No.

A5296

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DDX5

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 69kDa/Observed: Refer to Figures

Formulation

DDX5 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DDX5 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

p68 antibody, HLR1 antibody, G17P1 antibody, HUMP68 antibody

Database links

Human UniProt/Swiss-Prot:P17844

Protein names

p68, HLR1, G17P1, HUMP68

Protein function

Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3′ transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.

Protein sequence and domain

Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.; Contains 1 helicase ATP-binding domain.; Contains 1 helicase C-terminal domain.

Protein post-translational modifications

Arg-502 is dimethylated, probably to asymmetric dimethylarginine.; Sumoylated; sumoylation, promoted by PIAS1, promotes interaction with HDAC1 and transcriptional repression activity. Sumoylation also significantly increases stability, and reduces polyubiquitination.; Polyubiquitinated, leading to proteasomal degradation.

Protein cellular localization

Nucleus, nucleolus .

Background

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.

Research area

All research areas>Transcription Regulators>p68 RNA Helicase
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize DDX5 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!