Rabbit polyclonal DEFA1 antibody (A6897)

$69.00$259.00

Reactivity: Human,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DEFA1 antibody (A6897)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal DEFA1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

HP1 antibody, MRS antibody, DEF1 antibody, HP-1 antibody, DEFA2 antibody, HNP-1 antibody
DEF1 antibody|DEF3 antibody|DEFA1 antibody|DEFA2 antibody|DEFA3 antibody|Defensin alpha 1 antibody|Defensin alpha 2 antibody|Defensin alpha 3 antibody|HNP1 antibody|HNP3 antibody|HP1 antibody|HP3 antibody|MRS antibody|Neutrophil defensin 1 antibody|Neutrophil defensin 2 antibody|Neutrophil defensin 3 antibody|Anti-alpha Defensin 1 + 2 + 3 antibody (ab99504)

SCBT cat No: sc-22915|

Name

Rabbit polyclonal DEFA1 antibody

Catalogue No.

A6897

Reactivity

Human, Rat

Immunogen

Recombinant protein of human DEFA1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 10kDa/Observed: Refer to figures

Formulation

DEFA1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DEFA1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HP1 antibody, MRS antibody, DEF1 antibody, HP-1 antibody, DEFA2 antibody, HNP-1 antibody

Database links

Human UniProt/Swiss-Prot:P59665

Protein names

HP1, MRS, DEF1, HP-1, DEFA2, HNP-1

Protein function

Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.

Protein sequence and domain

Belongs to the alpha-defensin family.

Protein post-translational modifications

ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production.; Phosphorylation at Tyr-85 has been found in some cancer cell lines, and interferes with ADP-ribosylation.

Protein cellular localization

Secreted.

Background

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.

Note

AntibodyPlus can customize DEFA1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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