Rabbit polyclonal DFFA antibody (A1032)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DFFA antibody (A1032)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal DFFA antibody.

Alternative names:

Check alternative names for the antibody

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DFFA antibody, DFF1 antibody, Inhibitor of CAD antibody, ICAD antibody, DFF 45 antibody, DFF45 antibody
A330085O09Rik antibody|Caspase activated deoxyribonuclease inhibitor short form antibody|DFF 1 antibody|DFF 45 antibody|DFF alpha antibody|DFF-45 antibody|DFF1 antibody|DFF35 antibody|DFF45 antibody|DFFA antibody|Dffa DNA fragmentation factor, alpha subunit antibody|DFFA_HUMAN antibody|DNA fragmentation factor 45 kDa subunit antibody|DNA Fragmentation Factor Alpha Subunit antibody|DNA fragmentation factor subunit alpha antibody|DNA fragmentation factor, 45 kD, alpha subunit antibody|DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1 antibody|DNA fragmentation factor, 45kDa, alpha polypeptide antibody|DNA fragmentation factor, alpha subunit antibody|DNAation factor 45 kDa subunit antibody|H13 antibody|ICAD antibody|ICAD L antibody|ICAD S antibody|Inhibitor of CAD antibody|Inhibitor of Caspase Activated DNase antibody|MGC143066 antibody|OTTHUMP00000001903 antibody|OTTHUMP00000001904 antibody|RP23 121D17.3 antibody|Anti-ICAD antibody [EPR4220] (ab108924)

SCBT cat No: sc-17818|sc-398431|sc-17816|sc-9066|sc-393886|

Name

Rabbit polyclonal DFFA antibody

Catalogue No.

A1032

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DFFA

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 37kDa/Observed: Refer to Figures

Formulation

DFFA antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DFFA antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DFFA antibody, DFF1 antibody, Inhibitor of CAD antibody, ICAD antibody, DFF 45 antibody, DFF45 antibody

Database links

Human UniProt/Swiss-Prot:O00273

Protein names

DFFA, DFF1, Inhibitor of CAD, ICAD, DFF 45, DFF45

Protein function

Inhibitor of the caspase-activated DNase (DFF40).

Protein sequence and domain

Contains 1 CIDE-N domain.

Protein post-translational modifications

Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.

Protein cellular localization

Cytoplasm.

Background

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF), a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits, is one of the major endonucleases responsible for internucleosomal DNA cleavage during apoptosis. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Assignment of the DNA fragmentation factor gene (DFFA) to human chromosome bands 1p36.3-2 by in situ hybridization

Research area

All research areas>Tumor Suppressor/Apoptosis>ICAD
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize DFFA antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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