Rabbit polyclonal DFNA5 antibody (A7432)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal DFNA5 antibody (A7432)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal DFNA5 antibody.

Alternative names:

Check alternative names for the antibody

Expand

ICERE-1 antibody
2310037D07Rik antibody|Non-syndromic hearing impairment protein 5 antibody|Nonsyndromic hearing impairment protein antibody|Anti-DFNA5 antibody – N-terminal (ab175614)

SCBT cat No: sc-79231|sc-79232|sc-393162|sc-366609|sc-79233|

Name

Rabbit polyclonal DFNA5 antibody

Catalogue No.

A7432

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DFNA5

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 55kDa/Observed: Refer to figures

Formulation

DFNA5 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DFNA5 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ICERE-1 antibody

Database links

Human UniProt/Swiss-Prot:O60443

Protein names

ICERE-1

Protein function

Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 . The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity . The physiological relevance of these observations is unknown (Probable).

Protein tissue specificity

Expressed in cochlea. Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta.

Protein sequence and domain

Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.Belongs to the gasdermin family.

Protein cellular localization

Cytoplasm, cytosol . Cell membrane .

Background

Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene.

Research area

All research areas>Tumor Suppressor/Apoptosis>DFNA5
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize DFNA5 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!