Rabbit polyclonal DHCR24 antibody (A5402)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DHCR24 antibody (A5402)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

DCE antibody, SELADIN1 antibody, Nbla03646 antibody, seladin-1 antibody
24 dehydrocholesterol reductase antibody|24-dehydrocholesterol reductase antibody|3 beta hydroxysterol delta 24 reductase antibody|3-beta-hydroxysterol delta-24-reductase antibody|DCE antibody|Delta(24)-sterol reductase antibody|Desmosterol to cholesterol enzyme antibody|DHC24_HUMAN antibody|Dhcr24 antibody|Diminuto dwarf1 homolog antibody|Diminuto/dwarf1 homolog antibody|KIAA0018 antibody|Nbla03646 antibody|Seladin-1 antibody|SELADIN1 antibody|Selective AD indicator 1 antibody|Selective Alzheimer’s Disease Indicator 1 antibody|Anti-Seladin 1 antibody (ab40490)

SCBT cat No: sc-398938|sc-390037|sc-48477|

Name

Rabbit polyclonal DHCR24 antibody

Catalogue No.

A5402

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DHCR24

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 60kDa/Observed: Refer to Figures

Formulation

DHCR24 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DHCR24 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DCE antibody, SELADIN1 antibody, Nbla03646 antibody, seladin-1 antibody

Database links

Human UniProt/Swiss-Prot:Q15392

Protein names

DCE, SELADIN1, Nbla03646, seladin-1

Protein function

Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.

Protein tissue specificity

Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.

Protein sequence and domain

Belongs to the FAD-binding oxidoreductase/transferase type 4 family.; Contains 1 FAD-binding PCMH-type domain.

Protein cellular localization

Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.

Background

This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

Note

AntibodyPlus can customize DHCR24 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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