Rabbit polyclonal DHRS2 antibody (A6446)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DHRS2 antibody (A6446)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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HEP27 antibody, SDR25C1 antibody
5430405K24Rik antibody|Dehydrogenase/reductase (SDR family) member 2 antibody|Dehydrogenase/reductase member 2 antibody|Dehydrogenase/reductase SDR family member 2 antibody|Dehydrogenase/reductase SDR family member 2 mitochondria antibody|Dicarbonyl reductase HEP27 antibody|Hep27 antibody|HEP27 protein antibody|MGC143467 antibody|Protein D antibody|SDR family member antibody|SDR25C1 antibody|Short chain alcohol dehydrogenase family member antibody|Short chain dehydrogenase/reductase family 25C member 1 antibody|Anti-DHRS2 antibody (ab83254)

SCBT cat No: sc-517054|sc-104879|

Name

Rabbit polyclonal DHRS2 antibody

Catalogue No.

A6446

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DHRS2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 29kDa/Observed: Refer to Figures

Formulation

DHRS2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DHRS2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HEP27 antibody, SDR25C1 antibody

Database links

Human UniProt/Swiss-Prot:Q13268

Protein names

HEP27, SDR25C1

Protein function

Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.

Protein tissue specificity

Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.

Protein sequence and domain

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein cellular localization

Mitochondrion matrix. Nucleus. Note: A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.

Background

DHRS2 (dehydrogenase/reductase (SDR family) member 2) is a protein-coding gene. Diseases associated with DHRS2 include otitis media, and hepatoblastoma. GO annotations related to this gene include carbonyl reductase (NADPH) activity. An important paralog of this gene is HPGD.

Research area

All research areas>Synthesis and Degradation>DHRS
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize DHRS2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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