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Rabbit polyclonal DIABLO antibody (A2564)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal DIABLO antibody.
Check alternative names for the antibodyExpand
SMAC antibody, DFNA64 antibody
0610041G12Rik antibody|DBLOH_HUMAN antibody|DBOH antibody|DFNA64 antibody|diablo antibody|Diablo homolog (Drosophila) antibody|Diablo homolog antibody|Diablo homolog mitochondrial antibody|Diablo IAP binding mitochondrial protein antibody|Diablo like protein antibody|DIABLO S antibody|Direct IAP binding protein with low pI antibody|Direct IAP-binding protein with low pI antibody|FLJ10537 antibody|FLJ25049 antibody|mitochondrial antibody|Mitochondrial Smac protein antibody|Second mitochondria derived activator of caspase antibody|Second mitochondria-derived activator of caspase antibody|SMAC 3 antibody|Smac antibody|Smac protein antibody|SMAC3 antibody|Anti-Smac / Diablo antibody [Y12] (ab32023)
SCBT cat No:
Rabbit polyclonal DIABLO antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human DIABLO
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 27kDa/Observed: Refer to Figures
DIABLO antibody was tube-contained.
DIABLO antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
SMAC antibody, DFNA64 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
|Protein tissue specificity|| |
Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.
|Protein sequence and domain|| |
The mature N-terminus mediates interaction with XIAP/BIRC4.
|Protein post-translational modifications|| |
Ubiquitinated by BIRC7/livin.
|Protein cellular localization|| |
Mitochondrion . Note: Released into the cytosol when cells undergo apoptosis.
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.
AntibodyPlus can customize DIABLO antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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