Rabbit polyclonal DIABLO antibody (A2564)


Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DIABLO antibody (A2564)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody


SMAC antibody, DFNA64 antibody
0610041G12Rik antibody|DBLOH_HUMAN antibody|DBOH antibody|DFNA64 antibody|diablo antibody|Diablo homolog (Drosophila) antibody|Diablo homolog antibody|Diablo homolog mitochondrial antibody|Diablo IAP binding mitochondrial protein antibody|Diablo like protein antibody|DIABLO S antibody|Direct IAP binding protein with low pI antibody|Direct IAP-binding protein with low pI antibody|FLJ10537 antibody|FLJ25049 antibody|mitochondrial antibody|Mitochondrial Smac protein antibody|Second mitochondria derived activator of caspase antibody|Second mitochondria-derived activator of caspase antibody|SMAC 3 antibody|Smac antibody|Smac protein antibody|SMAC3 antibody|Anti-Smac / Diablo antibody [Y12] (ab32023)

SCBT cat No:


Rabbit polyclonal DIABLO antibody

Catalogue No.



Human, Mouse, Rat


Recombinant protein of human DIABLO





Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200







Molecular weight

Predicted: 27kDa/Observed: Refer to Figures


DIABLO antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


DIABLO antibody was purified using affinity purification.


Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SMAC antibody, DFNA64 antibody

Database links

Human UniProt/Swiss-Prot:Q9NR28

Protein names


Protein function

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

Protein tissue specificity

Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.

Protein sequence and domain

The mature N-terminus mediates interaction with XIAP/BIRC4.

Protein post-translational modifications

Ubiquitinated by BIRC7/livin.

Protein cellular localization

Mitochondrion . Note: Released into the cytosol when cells undergo apoptosis.


This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.


AntibodyPlus can customize DIABLO antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody


ABclonal Inc.


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