Rabbit polyclonal DIABLO antibody (A2564)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal DIABLO antibody (A2564)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal DIABLO antibody.

Alternative names:

Check alternative names for the antibody

Expand

SMAC antibody, DFNA64 antibody
0610041G12Rik antibody|DBLOH_HUMAN antibody|DBOH antibody|DFNA64 antibody|diablo antibody|Diablo homolog (Drosophila) antibody|Diablo homolog antibody|Diablo homolog mitochondrial antibody|Diablo IAP binding mitochondrial protein antibody|Diablo like protein antibody|DIABLO S antibody|Direct IAP binding protein with low pI antibody|Direct IAP-binding protein with low pI antibody|FLJ10537 antibody|FLJ25049 antibody|mitochondrial antibody|Mitochondrial Smac protein antibody|Second mitochondria derived activator of caspase antibody|Second mitochondria-derived activator of caspase antibody|SMAC 3 antibody|Smac antibody|Smac protein antibody|SMAC3 antibody|Anti-Smac / Diablo antibody [Y12] (ab32023)

SCBT cat No:

Name

Rabbit polyclonal DIABLO antibody

Catalogue No.

A2564

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DIABLO

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 27kDa/Observed: Refer to Figures

Formulation

DIABLO antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DIABLO antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SMAC antibody, DFNA64 antibody

Database links

Human UniProt/Swiss-Prot:Q9NR28

Protein names

SMAC, DFNA64

Protein function

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

Protein tissue specificity

Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.

Protein sequence and domain

The mature N-terminus mediates interaction with XIAP/BIRC4.

Protein post-translational modifications

Ubiquitinated by BIRC7/livin.

Protein cellular localization

Mitochondrion . Note: Released into the cytosol when cells undergo apoptosis.

Background

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.

Note

AntibodyPlus can customize DIABLO antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!