Rabbit Polyclonal DIAPH3 antibody (A10351)

$99.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal DIAPH3 antibody (A10351)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

AN antibody; DIA2 antibody; DRF3 antibody; AUNA1 antibody; NSDAN antibody; diap3 antibody; mDia2 antibody;
AN antibody|Diaphanous, Drosophila, homolog of, 3 antibody|DKFZp434C0931 antibody|DKFZp686A13178 antibody|DRF3 antibody|FLJ34705 antibody|mDia2 antibody|NSDAN antibody|OTTHUMP00000018480 antibody|Protein diaphanous homolog 3 antibody|RP11-26P21.1 antibody|Anti-DIAPH3 antibody (ab77678)

SCBT cat No: sc-293288|sc-68067|sc-135261|

Name

Rabbit Polyclonal DIAPH3 antibody

Catalogue No.

A10351

Reactivity

Human

Immunogen

Recombinant protein of human DIAPH3

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

131kDa

Formulation

DIAPH3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

AN antibody; DIA2 antibody; DRF3 antibody; AUNA1 antibody; NSDAN antibody; diap3 antibody; mDia2 antibody;

Protein names

AN; DIA2; DRF3; AUNA1; NSDAN; diap3; mDia2;

Protein function

Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity).

Protein sequence and domain

Belongs to the formin homology family. Diaphanous subfamily.; Contains 1 DAD (diaphanous autoregulatory) domain.; Contains 1 FH1 (formin homology 1) domain.; Contains 1 FH2 (formin homology 2) domain.; Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).

Protein post-translational modifications

Ubiquitinated.

Protein cellular localization

Cytoplasm, cytosol . Note=During mitosis, co-localizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis.

Background

This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been found for this gene.

Note

AntibodyPlus can customize DIAPH3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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