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Rabbit polyclonal DISC1 antibody (A2898)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal DISC1 antibody.
Check alternative names for the antibodyExpand
SCZD9 antibody,C1orf136 antibody
C1orf136 antibody|DISC1 antibody|DISC1_HUMAN antibody|Disrupted in schizophrenia 1 antibody|Disrupted in schizophrenia 1 protein antibody|KIAA0457 antibody|RP4-730B13.1 antibody|SCZD9 antibody|Anti-DISC1 antibody [EPR14684] (ab192258)
SCBT cat No: sc-47990|
Rabbit polyclonal DISC1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
A synthetic peptide of human DISC1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 60kDa/Observed: Refer to Figures
DISC1 antibody was tube-contained.
DISC1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
SCZD9 antibody,C1orf136 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
|Protein tissue specificity|| |
Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter.
|Protein cellular localization|| |
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Note: Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome.
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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|Product type|| |
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