Rabbit polyclonal DKK3 antibody (A2527)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DKK3 antibody (A2527)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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RIG antibody, REIC antibody
Dickkopf 3 antibody|Dickkopf3 antibody|DKK 3 antibody|Dkk-3 antibody|DKK3 antibody|DKK3_HUMAN antibody|hDkk 3 antibody|hDkk-3 antibody|hDkk3 antibody|Regulated in glioma antibody|REIC antibody|RIG antibody|RIG-like 5-6 antibody|RIG-like 7-1 antibody|Anti-Dkk3 antibody [EPR15611] (ab186409)

SCBT cat No: sc-517200|sc-14959|sc-25518|sc-14956|

Name

Rabbit polyclonal DKK3 antibody

Catalogue No.

A2527

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DKK3

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 38kDa/Observed: Refer to Figures

Formulation

DKK3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DKK3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

RIG antibody, REIC antibody

Database links

Human UniProt/Swiss-Prot:Q9UBP4

Protein names

RIG, REIC

Protein function

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Protein tissue specificity

Highest expression in heart, brain, and spinal cord.

Protein sequence and domain

The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.Belongs to the dickkopf family.

Protein post-translational modifications

N- and O-glycosylated.

Protein cellular localization

Secreted.

Background

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.

Note

AntibodyPlus can customize DKK3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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