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Rabbit polyclonal DKK3 antibody (A2527)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal DKK3 antibody.
Check alternative names for the antibodyExpand
RIG antibody, REIC antibody
Dickkopf 3 antibody|Dickkopf3 antibody|DKK 3 antibody|Dkk-3 antibody|DKK3 antibody|DKK3_HUMAN antibody|hDkk 3 antibody|hDkk-3 antibody|hDkk3 antibody|Regulated in glioma antibody|REIC antibody|RIG antibody|RIG-like 5-6 antibody|RIG-like 7-1 antibody|Anti-Dkk3 antibody [EPR15611] (ab186409)
SCBT cat No: sc-517200|sc-14959|sc-25518|sc-14956|
Rabbit polyclonal DKK3 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human DKK3
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 38kDa/Observed: Refer to Figures
DKK3 antibody was tube-contained.
DKK3 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
RIG antibody, REIC antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
|Protein tissue specificity|| |
Highest expression in heart, brain, and spinal cord.
|Protein sequence and domain|| |
The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.Belongs to the dickkopf family.
|Protein post-translational modifications|| |
N- and O-glycosylated.
|Protein cellular localization|| |
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.
AntibodyPlus can customize DKK3 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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