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Rabbit polyclonal DLG1 antibody (A8542)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal DLG1 antibody.
Check alternative names for the antibodyExpand
Discs large homolog 1 antibody|discs large, Drosophila, homolog of, 1 antibody|discs, large homolog 1 (Drosophila) antibody|Disks large homolog 1 antibody|dJ1061C18.1.1 antibody|DKFZp761P0818 antibody|DKFZp781B0426 antibody|DLG 1 antibody|DLG1 antibody|DLG1_HUMAN antibody|DLGH 1 antibody|DLGH1 antibody|hDlg antibody|Presynaptic protein SAP97 antibody|SAP 97 antibody|SAP-97 antibody|SAP97 antibody|Synapse associated protein 97 antibody|Synapse-associated protein 97 antibody|Anti-SAP97 antibody (ab3437)
SCBT cat No: sc-9961|sc-514478|sc-25661|sc-26530|sc-26532|
Rabbit polyclonal DLG1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human DLG1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 100kDa/Observed: Refer to figures
DLG1 antibody was tube-contained.
DLG1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.
|Protein tissue specificity|| |
Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expression profiles.
|Protein sequence and domain|| |
The alternatively spliced domain I3 corresponding to amino acids (636-669) of isoform 4 is an EPB41 binding site mediating association to membranes in polarized and non-polarized cells.; The PDZ domains may also mediate association to membranes by binding to EPB41 and ADGRA2 together with the L27 domain that binds CASK and DLG2.; The L27 domain may regulate DLG1 self-association. The N-terminal alternatively spliced region is capable of binding several SH3 domains and also moderates the level of protein oligomerization.Belongs to the MAGUK family.; Contains 1 guanylate kinase-like domain.; Contains 1 L27 domain.; Contains 3 PDZ (DHR) domains.; Contains 1 SH3 domain.
|Protein post-translational modifications|| |
Phosphorylated by MAPK12. Phosphorylation of Ser-232 regulates association with GRIN2A (By similarity).
|Protein cellular localization|| |
Membrane ; Peripheral membrane protein . Basolateral cell membrane . Endoplasmic reticulum membrane . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell junction, synapse. Cell membrane, sarcolemma. Note: Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity).
AntibodyPlus can customize DLG1 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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Antibody customer reviews & validation data - 138
Validation data ID: 138
Submission date: 2017-03-03
IP studies were done to test if endogenous DLG1 is co precipitated with the protein of our interest. As evident from our blot DLG1 is enriched with the protein of our interest ( lane4) and not in the negative control ( lane3).
Rabbit polyclonal DLG1 antibody
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Antibody specificity rating
Antibody overall rating
This antibody was used to detect DLG1 from a lysates prepared from two cell lines HEK 293T and MDA MB231, that were mixed and used for immunoprecipitation studies
There is no extra validation for this product yet.
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