Rabbit polyclonal DLG4 antibody (A7889)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DLG4 antibody (A7889)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

PSD95 antibody, SAP90 antibody, SAP-90 antibody
Discs large homolog 4 antibody|Disks large homolog 4 antibody|DLG 4 antibody|Dlg4 antibody|DLG4_HUMAN antibody|FLJ97752 antibody|FLJ98574 antibody|Human post synaptic density protein 95 antibody|Post synaptic density protein 95 antibody|Postsynaptic density protein 95 antibody|PSD 95 antibody|PSD-95 antibody|PSD95 antibody|SAP 90 antibody|SAP-90 antibody|SAP90 antibody|Synapse associated protein 90 antibody|Synapse-associated protein 90 antibody|Tax interaction protein 15 antibody|Anti-PSD95 antibody (ab18258)

SCBT cat No: sc-71935|sc-71936|sc-71937|sc-71938|sc-71933|sc-71934|sc-32291|sc-32290|sc-8575|sc-28941|sc-6926|

Name

Rabbit polyclonal DLG4 antibody

Catalogue No.

A7889

Reactivity

Human, Mouse

Immunogen

A synthetic peptide of human DLG4

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 80kDa/Observed: Refer to figures

Formulation

DLG4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DLG4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PSD95 antibody, SAP90 antibody, SAP-90 antibody

Database links

Human UniProt/Swiss-Prot:P78352

Protein names

PSD95, SAP90, SAP-90

Protein function

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).

Protein tissue specificity

Brain.

Protein sequence and domain

The PDZ domain 3 mediates interaction with ADR1B.; The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density.Belongs to the MAGUK family.; Contains 1 guanylate kinase-like domain.; Contains 3 PDZ (DHR) domains.; Contains 1 SH3 domain.

Protein post-translational modifications

Palmitoylation of isoform 1 is required for targeting to postsynaptic density.

Protein cellular localization

Cell membrane ; Peripheral membrane protein . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell projection, axon . Cell junction, synapse . Note: High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.

Background

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Neurobiology>Post-Synaptic Density Protein
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize DLG4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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