Rabbit polyclonal DNAJA3 antibody (A7030)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DNAJA3 antibody (A7030)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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TID1 antibody, HCA57 antibody, hTID-1 antibody
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SCBT cat No:

Name

Rabbit polyclonal DNAJA3 antibody

Catalogue No.

A7030

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DNAJA3

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 52kDa/Observed: Refer to figures

Formulation

DNAJA3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DNAJA3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

TID1 antibody, HCA57 antibody, hTID-1 antibody

Database links

Human UniProt/Swiss-Prot:Q96EY1

Protein names

TID1, HCA57, hTID-1

Protein function

Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.

Protein tissue specificity

Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.

Protein sequence and domain

Modulation of apoptosis, i.e. proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J domain-dependent.Contains 1 CR-type zinc finger.; Contains 1 J domain.

Protein post-translational modifications

Tyrosine phosphorylated.

Protein cellular localization

Mitochondrion matrix. Cytoplasm, cytosol . Cell junction, synapse, postsynaptic cell membrane ; Peripheral membrane protein . Note: Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK.

Background

This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Note

AntibodyPlus can customize DNAJA3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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