Rabbit polyclonal DNAJB6 antibody (A7052)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal DNAJB6 antibody (A7052)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal DNAJB6 antibody.

Alternative names:

Check alternative names for the antibody

Expand

DJ4 antibody, MRJ antibody, DnaJ antibody, HSJ2 antibody, HHDJ1 antibody, HSJ-2 antibody, MSJ-1 antibody, LGMD1D antibody, LGMD1E antibody
DJ4 antibody|DnaJ antibody|DnaJ (Hsp40) homolog subfamily B member 6 antibody|DNAJ B6 antibody|DnaJ homolog subfamily B member 6 antibody|DnaJ like 2 protein antibody|DNAJB6 antibody|DNJB6_HUMAN antibody|Heat shock protein J2 antibody|HHDJ1 antibody|HSJ-2 antibody|HSJ2 antibody|LGMD1E antibody|MRJ antibody|MSJ-1 antibody|MSJ1 antibody|Anti-DNAJB6 antibody [EPR17122] – N-terminal (ab198995)

SCBT cat No: sc-365574|sc-104204|sc-365573|sc-100710|

Name

Rabbit polyclonal DNAJB6 antibody

Catalogue No.

A7052

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DNAJB6

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 36kDa/Observed: Refer to figures

Formulation

DNAJB6 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DNAJB6 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DJ4 antibody, MRJ antibody, DnaJ antibody, HSJ2 antibody, HHDJ1 antibody, HSJ-2 antibody, MSJ-1 antibody, LGMD1D antibody, LGMD1E antibody

Database links

Human UniProt/Swiss-Prot:O75190

Protein names

DJ4, MRJ, DnaJ, HSJ2, HHDJ1, HSJ-2, MSJ-1, LGMD1D, LGMD1E

Protein function

Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.

Protein tissue specificity

Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus.

Protein sequence and domain

The antiaggregation activity of isoform B resides in the serine-rich region and the C-terminus.Contains 1 J domain.

Protein cellular localization

Cytoplasm, perinuclear region . Nucleus . Cytoplasm, myofibril, sarcomere, Z line .

Background

This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the ‘J-domain’ and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.

Research area

All research areas>Signaling Intermediates>DnaJ
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize DNAJB6 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!