Rabbit polyclonal DOK4 antibody (A0226)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DOK4 antibody (A0226)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

DOK4 antibody, docking protein 4 antibody, FLJ10488 antibody, Insulin receptor substrate 5 antibody, IRS5 antibody, IRS 5 antibody
docking protein 4 antibody|Downstream of tyrosine kinase 4 antibody|FLJ10488 antibody|insulin receptor substrate 5 antibody|IRS5 antibody|Anti-DOK4 antibody (ab175624)

SCBT cat No:

Name

Rabbit polyclonal DOK4 antibody

Catalogue No.

A0226

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Protein of human DOK4

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 37kDa/Observed: Refer to Figures

Formulation

DOK4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DOK4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DOK4 antibody, docking protein 4 antibody, FLJ10488 antibody, Insulin receptor substrate 5 antibody, IRS5 antibody, IRS 5 antibody

Database links

Human UniProt/Swiss-Prot:Q8TEW6

Protein names

DOK4, docking protein 4, FLJ10488, Insulin receptor substrate 5, IRS5, IRS 5

Protein function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.

Protein tissue specificity

Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.

Protein sequence and domain

PTB domain mediates receptor interaction.Belongs to the DOK family. Type B subfamily.; Contains 1 IRS-type PTB domain.; Contains 1 PH domain.

Protein post-translational modifications

Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation.

Background

The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.

Note

AntibodyPlus can customize DOK4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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