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Rabbit Polyclonal Doublecortin antibody (STJ92771)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Doublecortin Polyclonal Antibody.
Check alternative names for the antibodyExpand
DCX antibody, DBCN antibody, LISX antibody,|DBCN antibody|Dbct antibody|DC antibody|DCX antibody|DCX_HUMAN antibody|Doublecortex antibody|Doublin antibody|FLJ51296 antibody|Lis X antibody|Lis-X antibody|Lissencephalin X antibody|Lissencephalin-X antibody|Lissencephaly X linked antibody|Lissencephaly X linked doublecortin antibody|LISX antibody|Neuronal migration protein doublecortin antibody|OTTHUMP00000023859 antibody|OTTHUMP00000023860 antibody|OTTHUMP00000216315 antibody|OTTHUMP00000216316 antibody|SCLH antibody|XLIS antibody|Anti-Doublecortin antibody (ab18723)
SCBT cat No: sc-8066|sc-390645|sc-271390|sc-28939|sc-8067|
Doublecortin Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Doublecortin Polyclonal Antibody detects endogenous levels of Doublecortin protein.
Synthesized peptide derived from Doublecortin at AA range 180-260
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;
|Molecular weight|| |
Doublecortin Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Doublecortin Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Neuronal migration protein doublecortin antibody, Doublin antibody, Lissencephalin-X antibody, Lis-X antibody
|Protein names|| |
Neuronal migration protein doublecortin , Doublin , Lissencephalin-X , Lis-X
|Protein function|| |
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.
|Protein tissue specificity|| |
Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.
|Involvement in disease|| |
Lissencephaly, X-linked 1 (LISX1) [MIM:300067]: A classic lissencephaly characterized by mental retardation and seizures that are more severe in male patients. Affected boys show an abnormally thick cortex with absent or severely reduced gyri. Clinical manifestations include feeding problems, abnormal muscular tone, seizures and severe to profound psychomotor retardation. Female patients display a less severe phenotype referred to as ‘doublecortex’. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Subcortical band heterotopia X-linked (SBHX) [MIM:300067]: SBHX is a mild brain malformation of the lissencephaly spectrum. It is characterized by bilateral and symmetric plates or bands of gray matter found in the central white matter between the cortex and cerebral ventricles, cerebral convolutions usually appearing normal. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Note: A chromosomal aberration involving DCX is found in lissencephaly. Translocation t(X;2)(q22.3;p25.1).
|Protein sequence and domain|| |
Contains 2 doublecortin domains.
|Protein post-translational modifications|| |
Phosphorylation by MARK1, MARK2 and PKA regulates its ability to bind microtubules. / Phosphorylation at Ser-265 and Ser-297 seems to occur only in neonatal brain, the levels falling precipitously by postnatal day 21.
|Protein cellular localization|| |
Cytoplasm / Cell projection
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St John’s Laboratory Ltd.
|Product type|| |
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