Rabbit polyclonal DPP4 antibody (A1455)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DPP4 antibody (A1455)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CD26 antibody, ADABP antibody, ADCP2 antibody, DPPIV antibody, TP103 antibody
CD26 antigen antibody|ADA-binding protein antibody|ADABP antibody|ADCP 2 antibody|ADCP-2 antibody|ADCP2 antibody|Adenosine deaminase complexing protein 2 antibody|CD 26 antibody|CD26 antibody|CD26 antigen 3 antibody|Dipeptidyl peptidase 4 antibody|Dipeptidyl peptidase 4 soluble form antibody|Dipeptidyl peptidase IV antibody|Dipeptidyl peptidase IV membrane form antibody|Dipeptidyl peptidase IV soluble form antibody|Dipeptidyl peptidase, intestinal antibody|Dipeptidylpeptidase 4 antibody|Dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2) antibody|Dipeptidylpeptidase IV antibody|DPP 4 antibody|DPP IV antibody|DPP IV estoenzyme antibody|DPP4 antibody|DPP4_HUMAN antibody|DPPIV antibody|Intestinal dipeptidyl peptidase antibody|T cell activation antigen CD26 antibody|T-cell activation antigen CD26 antibody|TP 103 antibody|TP103 antibody|Anti-CD26 antibody (ab28340)

SCBT cat No: sc-7044|

Name

Rabbit polyclonal DPP4 antibody

Catalogue No.

A1455

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DPP4

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 110kDa/Observed: Refer to Figures

Formulation

DPP4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DPP4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CD26 antibody, ADABP antibody, ADCP2 antibody, DPPIV antibody, TP103 antibody

Database links

Human UniProt/Swiss-Prot:P27487

Protein names

CD26, ADABP, ADCP2, DPPIV, TP103

Protein function

Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

Protein tissue specificity

Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.

Protein sequence and domain

The extracellular cysteine-rich region is necessary for association with collagen, dimer formation and optimal dipeptidyl peptidase activity.Belongs to the peptidase S9B family. DPPIV subfamily.

Protein post-translational modifications

The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing.; N- and O-Glycosylated.; Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation.

Protein cellular localization

Dipeptidyl peptidase 4 soluble form: Secreted . Note: Detected in the serum and the seminal fluid.; Cell membrane ; Single-pass type II membrane protein. Apical cell membrane ; Single-pass type II membrane protein. Cell projection, invadopodium membrane ; Single-pass type II membrane protein. Cell projection, lamellipodium membrane ; Single-pass type II membrane protein. Cell junction . Membrane raft . Note: Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids . Redistributed to membrane rafts in T-cell in a interleukin-12-dependent activation . Its interaction with CAV1 is necessary for its translocation to membrane rafts . Colocalized with PTPRC in membrane rafts . Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma . Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion . Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface .

Background

CD26 is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides (1).

Research area

All research areas>Lymphocyte Signaling>CD26
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize DPP4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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