Rabbit polyclonal DPYD antibody (A1620)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DPYD antibody (A1620)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal DPYD antibody.

Alternative names:

Check alternative names for the antibody

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DHP antibody, DPD antibody, DHPDHASE antibody
DHP antibody|DHPDHase antibody|Dihydropyrimidine dehydrogenase [NADP(+)] antibody|Dihydropyrimidine dehydrogenase [NADP+] antibody|Dihydropyrimidine dehydrogenase antibody|Dihydrothymine dehydrogenase antibody|Dihydrouracil dehydrogenase antibody|DPD antibody|DPYD antibody|DPYD_HUMAN antibody|MGC132008 antibody|MGC70799 antibody|OTTHUMP00000058954 antibody|Anti-DPYD antibody (ab54797)

SCBT cat No: sc-376712|sc-34065|sc-271308|sc-376681|sc-50521|

Name

Rabbit polyclonal DPYD antibody

Catalogue No.

A1620

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DPYD

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 110kDa/Observed: Refer to Figures

Formulation

DPYD antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DPYD antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DHP antibody, DPD antibody, DHPDHASE antibody

Database links

Human UniProt/Swiss-Prot:Q12882

Protein names

DHP, DPD, DHPDHASE

Protein function

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.

Protein tissue specificity

Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.

Protein sequence and domain

Belongs to the dihydropyrimidine dehydrogenase family.; Contains 3 4Fe-4S ferredoxin-type domains.

Protein cellular localization

Cytoplasm.

Background

Dihydropyrimidine dehydrogenase (DPD, DPYD) catalyzes the initial and rate-limiting step in uracil and thymidine catabolism as well as catabolism of the chemotherapeutic drug 5-fluorouracil (5-FU) and its derivatives. DPYD deficiency, which results from mutations in the DPYD gene, causes errors in pyrimidine metabolism and potentially life-threatening side effects in cancer patients treated with 5-FU (reviewed in 1). As a result, ongoing work examines whether or how DPYD gene variation and protein expression can be used to predict 5-FU toxicity (1,2). Several genes that impart resistance to 5-FU were recently identified in human hepatocellular carcinoma (HCC). AEG-1, which is highly expressed in HCC, increases the expression of DPYD. DPYD is expressed more highly in HCC than in normal liver, and this is thought to be one mechanism of 5-FU resistance (3,4).

Research area

All research areas>Synthesis and Degradation>DPYD
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize DPYD antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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