Rabbit polyclonal DR1 antibody (A6903)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DR1 antibody (A6903)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

NC2 antibody, NC2-BETA antibody
Down regulator of transcription 1 antibody|Down regulator of transcription 1 TBP binding antibody|Down-regulator of transcription 1 antibody|down-regulator of transcription 1, TBP-binding (negative cofactor 2) antibody|DR 1 antibody|Dr1 antibody|Dr1 protein antibody|NC 2 antibody|NC2 antibody|NC2 beta antibody|NC2-beta antibody|NC2B_HUMAN antibody|Negative co factor 2 antibody|Negative cofactor 2 antibody|Negative cofactor 2 beta antibody|Negative cofactor 2-beta antibody|Protein Dr1 antibody|TATA binding protein associated phosphoprotein antibody|TATA box/binding protein associated phosphoprotein DR1 antibody|TATA-binding protein-associated phosphoprotein antibody|Anti-DR1 antibody (ab88597)

SCBT cat No: sc-515024|sc-515083|sc-367195|

Name

Rabbit polyclonal DR1 antibody

Catalogue No.

A6903

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DR1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 19kDa/Observed: Refer to figures

Formulation

DR1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DR1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NC2 antibody, NC2-BETA antibody

Database links

Human UniProt/Swiss-Prot:Q01658

Protein names

NC2, NC2-BETA

Protein function

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Protein sequence and domain

Belongs to the NC2 beta/DR1 family.; Contains 1 histone-fold domain.

Protein post-translational modifications

Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.

Protein cellular localization

Nucleus.

Background

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

Note

AntibodyPlus can customize DR1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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