Rabbit polyclonal DROSHA antibody (A8336)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DROSHA antibody (A8336)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal DROSHA antibody.

Alternative names:

Check alternative names for the antibody

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RN3 antibody, ETOHI2 antibody, RNASEN antibody, RANSE3L antibody, RNASE3L antibody, HSA242976 antibody
DROSHA antibody|Drosha double stranded RNA specific endoribonuclease antibody|Drosha ribonuclease type III antibody|Etohi2 antibody|HSA242976 antibody|Nuclear RNase III Drosha antibody|p241 antibody|Protein Drosha antibody|Putative protein p241 which interacts with transcription factor Sp1 antibody|Putative ribonuclease III antibody|RANSE3L antibody|Ribonuclease 3 antibody|Ribonuclease III antibody|Ribonuclease III nuclear antibody|Ribonuclease type III nuclear antibody|RibonucleaseIII antibody|RN 3 antibody|RN3 antibody|RNase 3 antibody|RNase III antibody|RNase3 antibody|RNASE3L antibody|RNaseIII antibody|RNASEN antibody|RNC_HUMAN antibody|Anti-Drosha antibody – ChIP Grade (ab12286)

SCBT cat No: sc-393591|sc-31159|sc-33778|

Name

Rabbit polyclonal DROSHA antibody

Catalogue No.

A8336

Reactivity

Human

Immunogen

A synthetic peptide of human DROSHA

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 159kDa/Observed: Refer to Figures

Formulation

DROSHA antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DROSHA antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

RN3 antibody, ETOHI2 antibody, RNASEN antibody, RANSE3L antibody, RNASE3L antibody, HSA242976 antibody

Database links

Human UniProt/Swiss-Prot:Q9NRR4

Protein names

RN3, ETOHI2, RNASEN, RANSE3L, RNASE3L, HSA242976

Protein function

Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3′ and 5′ strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

The 2 RNase III domains form an intramolecular dimer where the domain 1 cuts the 3’strand while the domain 2 cleaves the 5’strand of pri-miRNAs, independently of each other.Contains 1 DRBM (double-stranded RNA-binding) domain.; Contains 2 RNase III domains.

Protein cellular localization

Nucleus . Nucleus, nucleolus . Note: A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies.

Background

Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).

Research area

All research areas>Transcription Regulators>RNase
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize DROSHA antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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