Rabbit polyclonal DUSP1 antibody (A2919)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DUSP1 antibody (A2919)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal DUSP1 antibody.

Alternative names:

Check alternative names for the antibody

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HVH1 antibody,MKP1 antibody,CL100 antibody,MKP-1 antibody,PTPN10 antibody
CL 100 antibody|CL100 antibody|Dual Specificity Phosphatase 1 antibody|Dual specificity protein phosphatase 1 antibody|Dual specificity protein phosphatase hVH1 antibody|DUS1_HUMAN antibody|DUSP 1 antibody|Dusp1 antibody|HVH1 antibody|MAP kinase phosphatase 1 antibody|Mitogen-activated protein kinase phosphatase 1 antibody|MKP-1 antibody|MKP1 antibody|Protein tyrosine phosphatase CL100 antibody|Protein-tyrosine phosphatase CL100 antibody|PTPN10 antibody|Serine/threonine specific protein phosphatase antibody|VH1 antibody|Anti-DUSP1 antibody [EPR18884] (ab195261)

SCBT cat No: sc-370|sc-271684|sc-373841|sc-10796|sc-1102|sc-1199|

Name

Rabbit polyclonal DUSP1 antibody

Catalogue No.

A2919

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human DUSP1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 39kDa/Observed: Refer to Figures

Formulation

DUSP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DUSP1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HVH1 antibody,MKP1 antibody,CL100 antibody,MKP-1 antibody,PTPN10 antibody

Database links

Human UniProt/Swiss-Prot:P28562

Protein names

HVH1,MKP1,CL100,MKP-1,PTPN10

Protein function

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ‘Thr-183’ and ‘Tyr-185’, regulating its activity during the meiotic cell cycle.

Protein tissue specificity

Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.

Protein sequence and domain

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.; Contains 1 rhodanese domain.; Contains 1 tyrosine-protein phosphatase domain.

Protein post-translational modifications

Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.

Protein cellular localization

Nucleus .

Background

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

Research area

All research areas>Kinases and Phosphatases>MKP
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize DUSP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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