Rabbit polyclonal DYRK1A antibody (A0595)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DYRK1A antibody (A0595)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:1000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal DYRK1A antibody.

Alternative names:

Check alternative names for the antibody

Expand

MNB antibody, DYRK antibody, HP86 antibody, MNBH antibody, MRD7 antibody, DYRK1 antibody
Dual specificity tyrosine phosphorylation regulated kinase antibody|DYR1A_HUMAN antibody|DYRK 1 antibody|DYRK 1A antibody|DYRK antibody|DYRK1 antibody|Dyrk1a antibody|DYRKA antibody|hMNB antibody|HP 86 antibody|HP86 antibody|Minibrain (Drosophila) homolog antibody|Minibrain homolog antibody|Minibrain, Drosophila, homolog of antibody|MNB antibody|MNB protein kinase antibody|Mnb protein kinase homolog hp86 antibody|MNB protein kinase, Serine/threonine-specific antibody|MNB/DYRK protein kinase antibody|MNBH antibody|MRD7 antibody|OTTHUMP00000109090 antibody|OTTHUMP00000109091 antibody|OTTHUMP00000109094 antibody|OTTHUMP00000174799 antibody|Protein kinase minibrain homolog antibody|Serine/threonine kinase MNB antibody|Anti-DYRK1A antibody (ab65220)

SCBT cat No: sc-12571|sc-12568|sc-28899|sc-100376|sc-130741|

Name

Rabbit polyclonal DYRK1A antibody

Catalogue No.

A0595

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DYRK1A

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:1000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 86kDa/Observed: Refer to Figures

Formulation

DYRK1A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DYRK1A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MNB antibody, DYRK antibody, HP86 antibody, MNBH antibody, MRD7 antibody, DYRK1 antibody

Database links

Human UniProt/Swiss-Prot:Q13627

Protein names

MNB, DYRK, HP86, MNBH, MRD7, DYRK1

Protein function

May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3.

Protein tissue specificity

Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.

Protein sequence and domain

The polyhistidine repeats act as targeting signals to nuclear speckles.Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.; Contains 1 protein kinase domain.

Protein post-translational modifications

Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro).

Protein cellular localization

Nucleus speckle.

Background

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5′ UTR or in the 3′ coding region. These variants encode at least five different isoforms.

Research area

All research areas>Kinases and Phosphatases>Dyrk
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize DYRK1A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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