Rabbit polyclonal E2F6 antibody (A6151)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP,ChIP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal E2F6 antibody (A6151)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF,IP,ChIP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:20 – 1:100 IP 1:20 – 1:100 CHIP 1:20 – 1:50

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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E2F-6 antibody
E2F 6 antibody|E2F binding site modulating activity protein antibody|E2F transcription factor 6 antibody|E2F transcription factor 6 isoform 1 antibody|E2F-6 antibody|E2F6 antibody|E2F6_HUMAN antibody|EMA antibody|MGC111545 antibody|Transcription factor E2F6 antibody|Anti-E2F6 antibody – ChIP Grade (ab53061)

SCBT cat No: sc-390022|sc-22823|

Name

Rabbit polyclonal E2F6 antibody

Catalogue No.

A6151

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human E2F6

Host

Rabbit

Applications

WB, IHC, IF, IP, ChIP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:20 – 1:100
IP 1:20 – 1:100
CHIP 1:20 – 1:50

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 32kDa/Observed: Refer to Figures

Formulation

E2F6 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

E2F6 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

E2F-6 antibody

Database links

Human UniProt/Swiss-Prot:O75461

Protein names

E2F-6

Protein function

Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5′-TTTC[CG]CGC-3′. Has a preference for the 5′-TTTCCCGC-3′ E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.

Protein tissue specificity

Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen.

Protein sequence and domain

Belongs to the E2F/DP family.

Protein cellular localization

Nucleus.

Background

This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants.

Research area

All research areas>Transcription Regulators>E2F
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize E2F6 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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