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Rabbit polyclonal E2F6 antibody (A6151)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF,IP,ChIP
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:20 – 1:100 IP 1:20 – 1:100 CHIP 1:20 – 1:50
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal E2F6 antibody.
Check alternative names for the antibodyExpand
E2F 6 antibody|E2F binding site modulating activity protein antibody|E2F transcription factor 6 antibody|E2F transcription factor 6 isoform 1 antibody|E2F-6 antibody|E2F6 antibody|E2F6_HUMAN antibody|EMA antibody|MGC111545 antibody|Transcription factor E2F6 antibody|Anti-E2F6 antibody – ChIP Grade (ab53061)
SCBT cat No: sc-390022|sc-22823|
Rabbit polyclonal E2F6 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human E2F6
WB, IHC, IF, IP, ChIP
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 32kDa/Observed: Refer to Figures
E2F6 antibody was tube-contained.
E2F6 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5′-TTTC[CG]CGC-3′. Has a preference for the 5′-TTTCCCGC-3′ E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
|Protein tissue specificity|| |
Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen.
|Protein sequence and domain|| |
Belongs to the E2F/DP family.
|Protein cellular localization|| |
This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants.
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|Product type|| |
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