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Rabbit polyclonal EEF2K antibody (A5404)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal EEF2K antibody.
Check alternative names for the antibodyExpand
eEF-2K antibody, HSU93850 antibody
C86191 antibody|Calcium/calmodulin dependent eukaryotic elongation factor 2 antibody|Calcium/calmodulin dependent eukaryotic elongation factor 2 kinase antibody|Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase antibody|Calmodulin dependent protein kinase III antibody|cb365 antibody|EC 188.8.131.52 antibody|eEF 2 kinase antibody|eEF 2K antibody|eEF-2 kinase antibody|eEF-2K antibody|Eef2k antibody|EEF2K protein antibody|EF2K_HUMAN antibody|Elongation factor 2 kinase antibody|Eukaryotic elongation factor 2 kinase antibody|fa04b08 antibody|HSU93850 antibody|kinase eEF2K antibody|MGC45041 antibody|SMEF2K antibody|wu:fa04b08 antibody|zgc:100973 antibody|Anti-EEF2K antibody [EP881Y] (ab45168)
SCBT cat No: sc-393366|sc-390710|sc-21642|sc-21641|sc-514961|sc-398028|sc-398019|sc-21758|sc-377439|sc-68481|sc-517178|
Rabbit polyclonal EEF2K antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human EEF2K
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 82kDa/Observed: Refer to Figures
EEF2K antibody was tube-contained.
EEF2K antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
eEF-2K antibody, HSU93850 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
|Protein sequence and domain|| |
The catalytic domain is located to N-terminal region. The neighbor region contains the calmodulin-binding domain.Belongs to the protein kinase superfamily. Alpha-type protein kinase family.; Contains 1 alpha-type protein kinase domain.
|Protein post-translational modifications|| |
Autophosphorylated at multiple residues, Thr-348 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-398 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-78 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-359 or RPS6KA1 and RPS6KB1 at Ser-366 instead decrease EEF2K activity and promote protein synthesis.
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment.
AntibodyPlus can customize EEF2K antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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