Rabbit polyclonal EHMT1 antibody (A8513)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal EHMT1 antibody (A8513)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal EHMT1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

GLP antibody, GLP1 antibody, KMT1D antibody, FP13812 antibody, EUHMTASE1 antibody, Eu-HMTase1 antibody, bA188C12.1 antibody
bA188C12.1 antibody|DKFZp667M072 antibody|EHMT 1 antibody|EHMT1 antibody|EHMT1_HUMAN antibody|Eu-HMTase1 antibody|Euchromatic histone lysine N methyltransferase 1 antibody|Euchromatic histone methyltransferase 1 antibody|Euchromatic histone-lysine N-methyltransferase 1 antibody|EUHMTASE1 antibody|FLJ12879 antibody|FP13812 antibody|G9a like protein 1 antibody|G9a like protein antibody|G9a-like protein 1 antibody|GLP 1 antibody|GLP antibody|GLP1 antibody|H3 K9 HMTase 5 antibody|H3-K9-HMTase 5 antibody|Histone H3 K9 methyltransferase 5 antibody|Histone H3-K9 methyltransferase 5 antibody|Histone lysine N methyltransferase H3 lysine 9 specific 5 antibody|Histone-lysine N-methyltransferase EHMT1 antibody|KIAA1876 antibody|Lysine N methyltransferase 1D antibody|Lysine N-methyltransferase 1D antibody|RP11 188C12.1 antibody|Anti-EHMT1/GLP antibody [B0422] – ChIP Grade (ab41969)

SCBT cat No: sc-68165|sc-130747|sc-68166|

Name

Rabbit polyclonal EHMT1 antibody

Catalogue No.

A8513

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human EHMT1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 141kDa/Observed: Refer to figures

Formulation

EHMT1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

EHMT1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GLP antibody, GLP1 antibody, KMT1D antibody, FP13812 antibody, EUHMTASE1 antibody, Eu-HMTase1 antibody, bA188C12.1 antibody

Database links

Human UniProt/Swiss-Prot:Q9H9B1

Protein names

GLP, GLP1, KMT1D, FP13812, EUHMTASE1, Eu-HMTase1, bA188C12.1

Protein function

Histone methyltransferase that specifically mono- and dimethylates ‘Lys-9’ of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates ‘Lys-27’ of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of ‘Lys-373’ of p53/TP53.

Protein tissue specificity

Widely expressed.

Protein sequence and domain

The ANK repeats recognize and bind RELA subunit of NF-kappa-B, when RELA is monomethylated at ‘Lys-310’ (By similarity). They also specifically recognize and bind H3K9me1 and H3K9me2.; The SET domain mediates interaction with WIZ.; In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.Belongs to the class V-like SAM-binding methyltransferase superfamily.; Contains 8 ANK repeats.; Contains 1 pre-SET domain.; Contains 1 SET domain.

Protein cellular localization

Nucleus. Chromosome. Note: Associates with euchromatic regions.

Background

The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants.

Research area

All research areas>Transcription Regulators>EHMT
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize EHMT1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!