Rabbit polyclonal ELAVL1 antibody (A1608)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ELAVL1 antibody (A1608)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:100 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ELAVL1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

HUR antibody, Hua antibody, MelG antibody, ELAV1 antibody
ELAV (embryonic lethal abnormal vision Drosophila) like 1 antibody|ELAV (embryonic lethal, abnormal vision, Drosophila) like 1 (Hu antigen R) antibody|ELAV like 1 antibody|ELAV like RNA binding protein 1 antibody|ELAV-like protein 1 antibody|ELAV1 antibody|ELAV1_HUMAN antibody|Elavl1 antibody|Embryonic lethal abnormal vision drosophila homolog like 1 antibody|Hu Antigen R antibody|Hu-antigen R antibody|Hua antibody|HuR antibody|MelG antibody|Anti-HuR / ELAVL1 antibody [EPR17397] (ab200342)

SCBT cat No: sc-374285|sc-365816|sc-20694|

Name

Rabbit polyclonal ELAVL1 antibody

Catalogue No.

A1608

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ELAVL1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:100 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 36kDa/Observed: Refer to Figures

Formulation

ELAVL1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ELAVL1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HUR antibody, Hua antibody, MelG antibody, ELAV1 antibody

Database links

Human UniProt/Swiss-Prot:Q15717

Protein names

HUR, Hua, MelG, ELAV1

Protein function

RNA-binding protein that binds to the 3′-UTR region of mRNAs and increases their stability . Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3′-UTR of target mRNAs . Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5′-UUUU[AG]UUU-3′ motif in vitro . With ZNF385A, binds the 3′-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity).

Protein tissue specificity

Ubiquitous. Detected in brain, liver, thymus and muscle.

Protein sequence and domain

The first RRM (RNA recognition motif) domain is essential for binding to AU-rich elements.Belongs to the RRM elav family.; Contains 3 RRM (RNA recognition motif) domains.

Protein post-translational modifications

Phosphorylated by MAPKAPK2 . Phosphorylated by PRKCD .; Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.

Protein cellular localization

Cytoplasm . Nucleus . Note: Translocates into the cytoplasm following phosphorylation by MAPKAPK2 . Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes .

Background

The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3′ untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]

Research area

All research areas>Transcription Regulators>Hu
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize ELAVL1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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