Rabbit polyclonal EPCAM antibody (A1177)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal EPCAM antibody (A1177)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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EPCAM antibody,CO-17A antibody,CO17-1A antibody,EGP antibody,EGP-2 antibody,EGP34 antibody,EGP40 antibody,ESA antibody,Ep-CAM antibody,GA733-2 antibody,KS1/4 antibody,KSA antibody,M4S1 antibody,MIC18 antibody,MK-1 antibody,TACST-1 antibody,TACSTD1 antibody,TROP1 antibody,hEGP-2 antibody,CD326 antibody
17 1A antibody|323/A3 antibody|Adenocarcinoma associated antigen antibody|Adenocarcinoma-associated antigen antibody|Antigen identified by monoclonal antibody AUA1 antibody|AUA1 antibody|CD326 antibody|CD326 antigen antibody|Cell surface glycoprotein Trop 1 antibody|Cell surface glycoprotein Trop 2 antibody|Cell surface glycoprotein Trop-1 antibody|CO 17A antibody|CO17 1A antibody|CO17A antibody|DIAR5 antibody|EGP 2 antibody|EGP antibody|EGP2 antibody|EGP314 antibody|EGP40 antibody|Ep CAM antibody|Ep-CAM antibody|EPCAM antibody|EPCAM_HUMAN antibody|EpCAM1 antibody|Epithelial cell adhesion molecule antibody|Epithelial Cell Adhesion Molecule Intracellular Domain (EpCAM-ICD) antibody|Epithelial cell surface antigen antibody|Epithelial cellular adhesion molecule antibody|Epithelial glycoprotein 1 antibody|Epithelial glycoprotein 314 antibody|Epithelial glycoprotein antibody|ESA antibody|GA733 1 antibody|GA733 2 antibody|GA733-2 antibody|gastrointestinal tumor-associated antigen 2, 35-KD glycoprotein antibody|gp4 antibody|hEGP 2 antibody|hEGP314 antibody|HNPCC8 antibody|Human epithelial glycoprotein 2 antibody|KS 1/4 antigen antibody|KS1/4 antibody|KSA antibody|Ly74 antibody|Lymphocyte antigen 74 antibody|M1S 1 antibody|M1S2 antibody|M4S1 antibody|Major gastrointestinal tumor associated protein GA733 2 antibody|Major gastrointestinal tumor-associated protein GA733-2 antibody|mEGP314 antibody|Membrane component chromosome 4 surface marker (35kD glycoprotein) antibody|Membrane component, chromosome 4, surface marker 1 antibody|Membrane component, chromosome 4, surface marker antibody|MIC18 antibody|MK 1 antibody|Protein 289A antibody|TACD1 antibody|TACSTD1 antibody|TROP1 antibody|Tumor associated calcium signal transducer 1 antibody|Tumor associated calcium signal transducer 2 precursor antibody|Tumor-associated calcium signal transducer 1 antibody|Anti-EpCAM antibody (ab71916)

SCBT cat No: sc-53532|

Name

Rabbit polyclonal EPCAM antibody

Catalogue No.

A1177

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human EPCAM

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 35kDa/Observed: Refer to Figures

Formulation

EPCAM antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

EPCAM antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

EPCAM antibody,CO-17A antibody,CO17-1A antibody,EGP antibody,EGP-2 antibody,EGP34 antibody,EGP40 antibody,ESA antibody,Ep-CAM antibody,GA733-2 antibody,KS1/4 antibody,KSA antibody,M4S1 antibody,MIC18 antibody,MK-1 antibody,TACST-1 antibody,TACSTD1 antibody,TROP1 antibody,hEGP-2 antibody,CD326 antibody

Database links

Human UniProt/Swiss-Prot:P16422

Protein names

EPCAM,CO-17A,CO17-1A,EGP,EGP-2,EGP34,EGP40,ESA,Ep-CAM,GA733-2,KS1/4,KSA,M4S1,MIC18,MK-1,TACST-1,TACSTD1,TROP1,hEGP-2,CD326

Protein function

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.

Protein tissue specificity

Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC’s differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.

Protein sequence and domain

Belongs to the EPCAM family.; Contains 1 thyroglobulin type-1 domain.

Protein post-translational modifications

Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.

Protein cellular localization

Lateral cell membrane ; Single-pass type I membrane protein . Cell junction, tight junction . Note: Colocalizes with CLDN7 at the lateral cell membrane and tight junction.

Background

Epithelial cell adhesion and activating molecule (EpCAM/CD326) is a transmembrane glycoprotein that mediates Ca2+-independent, homophilic adhesions on the basolateral surface of most epithelial cells. EpCAM is not expressed in adult squamous epithelium, but it is highly expressed in adeno and squamous cell carcinomas (1). Research studies identified EpCAM as one of the first tumor-associated antigens, and it has long been a marker of epithelial and tumor tissue. Investigators have shown that EpCAM is highly expressed in cancer cells (reviewed in 2,3).

Note

AntibodyPlus can customize EPCAM antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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