Rabbit polyclonal EPHA1 antibody (A7328)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal EPHA1 antibody (A7328)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal EPHA1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

EPH antibody, EPHT antibody, EPHT1 antibody
EPH antibody|EPH receptor A1 antibody|EPH tyrosine kinase 1 antibody|EPH tyrosine kinase antibody|Epha1 antibody|EPHA1_HUMAN antibody|Ephrin receptor Eph A1 antibody|Ephrin type A receptor 1 antibody|Ephrin type-A receptor 1 antibody|EPHT 1 antibody|EPHT antibody|EPHT1 antibody|Erythropoietin producing hepatoma amplified sequence antibody|Erythropoietin-producing hepatoma receptor antibody|Esk antibody|hEpha1 antibody|MGC163163 antibody|Oncogene EPH antibody|Soluble EPHA1 variant 1 antibody|Soluble EPHA1 variant 2 antibody|Tyrosine protein kinase receptor EPH antibody|Tyrosine-protein kinase receptor EPH antibody|Anti-Eph receptor A1 antibody (ab5376)

SCBT cat No: sc-65994|sc-65993|sc-31257|sc-925|sc-20738|

Name

Rabbit polyclonal EPHA1 antibody

Catalogue No.

A7328

Reactivity

Human

Immunogen

Recombinant protein of human EPHA1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 108kDa/Observed: Refer to figures

Formulation

EPHA1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

EPHA1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

EPH antibody, EPHT antibody, EPHT1 antibody

Database links

Human UniProt/Swiss-Prot:P21709

Protein names

EPH, EPHT, EPHT1

Protein function

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Protein tissue specificity

Overexpressed in several carcinomas.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.; Contains 1 Eph LBD (Eph ligand-binding) domain.; Contains 2 fibronectin type-III domains.; Contains 1 protein kinase domain.; Contains 1 SAM (sterile alpha motif) domain.

Protein post-translational modifications

Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.; Ubiquitinated.

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein .

Background

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.

Research area

All research areas>Membrane Receptors>Eph
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize EPHA1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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