Rabbit polyclonal EPHA3 antibody (A8414)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal EPHA3 antibody (A8414)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal EPHA3 antibody.

Alternative names:

Check alternative names for the antibody

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EK4 antibody, ETK antibody, HEK antibody, ETK1 antibody, HEK4 antibody, TYRO4 antibody
AW492086 antibody|Cek4 antibody|EC 2.7.10.1 antibody|EK4 antibody|End3 antibody|Eph receptor A3 antibody|EPH-like kinase 4 antibody|EPH-like tyrosine kinase 1 antibody|EPHA3 antibody|EPHA3_HUMAN antibody|Ephrin receptor EphA3 antibody|Ephrin type-A receptor 3 antibody|ETK 1 antibody|ETK antibody|ETK1 antibody|HEK 4 antibody|HEK antibody|HEK4 antibody|Human embryo kinase 1 antibody|Human embryo kinase antibody|Mek4 antibody|MGC109882 antibody|Receptor tyrosine kinase HEK antibody|Testicular tissue protein Li 64 antibody|Tyro 4 antibody|Tyro4 antibody|TYRO4 protein tyrosine kinase antibody|Tyrosine protein kinase receptor ETK 1 antibody|Tyrosine-protein kinase receptor ETK1 antibody|Tyrosine-protein kinase TYRO4 antibody|Anti-Eph receptor A3 antibody – N-terminal (ab177910)

SCBT cat No: sc-134330|sc-919|sc-920|

Name

Rabbit polyclonal EPHA3 antibody

Catalogue No.

A8414

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human EPHA3

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 110kDa/Observed: Refer to figures

Formulation

EPHA3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

EPHA3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

EK4 antibody, ETK antibody, HEK antibody, ETK1 antibody, HEK4 antibody, TYRO4 antibody

Database links

Human UniProt/Swiss-Prot:P29320

Protein names

EK4, ETK, HEK, ETK1, HEK4, TYRO4

Protein function

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.

Protein tissue specificity

Widely expressed. Highest level in placenta.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.; Contains 1 Eph LBD (Eph ligand-binding) domain.; Contains 2 fibronectin type-III domains.; Contains 1 protein kinase domain.; Contains 1 SAM (sterile alpha motif) domain.

Protein post-translational modifications

Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1.

Protein cellular localization

Isoform 1: Cell membrane ; Single-pass type I membrane protein .; Isoform 2: Secreted .

Background

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.

Research area

All research areas>Membrane Receptors>Eph
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize EPHA3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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