Rabbit polyclonal EPHA4 antibody (A8346)

$69.00$259.00

Reactivity: Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal EPHA4 antibody (A8346)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal EPHA4 antibody.

Alternative names:

Check alternative names for the antibody

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SEK antibody, HEK8 antibody, TYRO1 antibody
Cek 8 antibody|CEK8 antibody|EK8 antibody|eph receptor a4 antibody|EPH-like kinase 8 antibody|EPHA4 antibody|EPHA4_HUMAN antibody|Ephrin type-A receptor 4 antibody|HEK 8 antibody|hEK8 antibody|Receptor protein-tyrosine kinase HEK8 antibody|Sek 1 antibody|SEK antibody|TYRO 1 protein tyrosine kinase antibody|TYRO1 antibody|Tyrosine-protein kinase receptor SEK antibody|Tyrosine-protein kinase TYRO1 antibody|Anti-Eph receptor A4 antibody (ab5389)

SCBT cat No: sc-135897|sc-922|sc-25457|sc-921|

Name

Rabbit polyclonal EPHA4 antibody

Catalogue No.

A8346

Reactivity

Mouse, Rat

Immunogen

Recombinant protein of human EPHA4

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 110kDa/Observed: Refer to figures

Formulation

EPHA4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

EPHA4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SEK antibody, HEK8 antibody, TYRO1 antibody

Database links

Human UniProt/Swiss-Prot:P54764

Protein names

SEK, HEK8, TYRO1

Protein function

Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at ‘Tyr-15’ which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

The protein kinase domain mediates interaction with NGEF.Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.; Contains 1 Eph LBD (Eph ligand-binding) domain.; Contains 2 fibronectin type-III domains.; Contains 1 protein kinase domain.; Contains 1 SAM (sterile alpha motif) domain.

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Early endosome . Note: Clustered upon activation and targeted to early endosome.

Background

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Membrane Receptors>Eph
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize EPHA4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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