Rabbit polyclonal EPHB2 antibody (A9813)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal EPHB2 antibody (A9813)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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cek5 antibody|DRT antibody|Eph receptor B2 antibody|EPH tyrosine kinase 3 antibody|EPH-like kinase 5 antibody|EPHB2 antibody|EPHB2_HUMAN antibody|Ephrin type B receptor 2 antibody|Ephrin type-B receptor 2 antibody|EPHT 3 antibody|ERK antibody|ETECK antibody|hEK5 antibody|Nuk antibody|Prkm 5 antibody|Receptor protein tyrosine kinase HEK 5 antibody|Renal carcinoma antigen NY-REN-47 antibody|Sek 3 antibody|Tyro 5 antibody|Tyrosine protein kinase receptor CEK 5 antibody|Tyrosine protein kinase receptor EPH 3 antibody|Tyrosine protein kinase receptor QEK 5 antibody|Tyrosine-protein kinase receptor EPH-3 antibody|Tyrosine-protein kinase TYRO5 antibody|Anti-Eph receptor B2 antibody (ab5418)

SCBT cat No: sc-130752|sc-27107|sc-1763|sc-28980|sc-100298|

Name

Rabbit polyclonal EPHB2 antibody

Catalogue No.

A9813

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human EPHB2

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 117kDa/Observed: Refer to figures

Formulation

EPHB2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

EPHB2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:P29323

Protein function

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.

Protein tissue specificity

Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.; Contains 1 Eph LBD (Eph ligand-binding) domain.; Contains 2 fibronectin type-III domains.; Contains 1 protein kinase domain.; Contains 1 SAM (sterile alpha motif) domain.

Protein cellular localization

Cell membrane; Single-pass type I membrane protein. Cell projection, axon . Cell projection, dendrite .

Research area

All research areas>Membrane Receptors>Eph
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize EPHB2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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