Rabbit polyclonal EPPIN antibody (A2149)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal EPPIN antibody (A2149)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

EPPIN antibody, EPPIN1 antibody, EPPIN2 antibody, EPPIN3 antibody, WAP7 antibody, WFDC7 antibody, dJ461P17.2 antibody,CT71 antibody, CT72 antibody, SPINLW1 antibody
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SCBT cat No:

Name

Rabbit polyclonal EPPIN antibody

Catalogue No.

A2149

Reactivity

Human, Mouse

Immunogen

Recombinant Protein of human EPPIN

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 15kDa/Observed: Refer to Figures

Formulation

EPPIN antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

EPPIN antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

EPPIN antibody, EPPIN1 antibody, EPPIN2 antibody, EPPIN3 antibody, WAP7 antibody, WFDC7 antibody, dJ461P17.2 antibody,CT71 antibody, CT72 antibody, SPINLW1 antibody

Database links

Human UniProt/Swiss-Prot:O95925

Protein names

EPPIN, EPPIN1, EPPIN2, EPPIN3, WAP7, WFDC7, dJ461P17.2,CT71, CT72, SPINLW1

Protein function

Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.

Protein tissue specificity

In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells.

Protein sequence and domain

The BPTI/Kunitz inhibitor domain is required for elastase inhibitory activity. BPTI/Kunitz inhibitor and WAP domains are involved in the protein antibacterial activity.Contains 1 BPTI/Kunitz inhibitor domain.; Contains 1 WAP domain.

Protein cellular localization

Isoform 1: Secreted. Cell surface. Note: Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa.

Background

This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. [provided by RefSeq, Nov 2010]

Note

AntibodyPlus can customize EPPIN antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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