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Rabbit polyclonal EPS15 antibody (A9814)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal EPS15 antibody.
Check alternative names for the antibodyExpand
AF 1P antibody|AF 1p protein antibody|AF1P antibody|ALL1 fused gene from chromosome 1 antibody|Epidermal growth factor receptor pathway substrate 15 antibody|Epidermal growth factor receptor substrate 15 antibody|EPS 15 antibody|MLLT 5 antibody|MLLT5 antibody|Protein Eps 15 antibody|Protein Eps15 antibody|Anti-EPS15 antibody [EP9280] (ab174291)
SCBT cat No: sc-135898|sc-534|sc-390259|sc-374578|sc-1840|sc-11716|
Rabbit polyclonal EPS15 antibody
|Catalogue No.|| |
Recombinant protein of human EPS15
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 99kDa/Observed: Refer to figures
EPS15 antibody was tube-contained.
EPS15 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.; The UIM (ubiquitin-interacting motif) repeats specifically bind ‘Lys-33’-linked ubiquitin.Contains 2 EF-hand domains.; Contains 3 EH domains.; Contains 2 UIM (ubiquitin-interacting motif) domains.
|Protein post-translational modifications|| |
Phosphorylation on Tyr-849 is involved in the internalization of EGFR. Not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis (By similarity). Phosphorylated on serine upon DNA damage, probably by ATM or ATR.; Ubiquitinated.
|Protein cellular localization|| |
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note: Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes.; Isoform 2: Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Note: Colocalizes with HGS on bilayered clathrin coats on endosomes.
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009]
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|Product type|| |
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