Rabbit polyclonal ERBB2IP antibody (A8585)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ERBB2IP antibody (A8585)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

LAP2 antibody, ERBIN antibody, HEL-S-78 antibody
Densin-180-like protein antibody|Erbb2-interacting protein antibody|Erbb2ip antibody|Erbin antibody|LAP2 antibody|LAP2_HUMAN antibody|Protein LAP2 antibody|Anti-Erbin antibody (ab55930)

SCBT cat No: sc-293468|sc-30054|sc-13249|

Name

Rabbit polyclonal ERBB2IP antibody

Catalogue No.

A8585

Reactivity

Human

Immunogen

Recombinant protein of human ERBB2IP

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 158kDa/Observed: Refer to figures

Formulation

ERBB2IP antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ERBB2IP antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

LAP2 antibody, ERBIN antibody, HEL-S-78 antibody

Database links

Human UniProt/Swiss-Prot:Q96RT1

Protein names

LAP2, ERBIN, HEL-S-78

Protein function

Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ‘Tyr-1248’ of receptor ERBB2, it may contribute to stabilize this unphosphorylated state . Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion .

Protein tissue specificity

Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.

Protein sequence and domain

Belongs to the LAP (LRR and PDZ) protein family.; Contains 17 LRR (leucine-rich) repeats.; Contains 1 PDZ (DHR) domain.

Protein cellular localization

Cell junction, hemidesmosome . Nucleus membrane . Basolateral cell membrane . Note: Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity).

Background

This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Note

AntibodyPlus can customize ERBB2IP antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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