Rabbit polyclonal ERBB3 antibody (A0950)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ERBB3 antibody (A0950)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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HER3 antibody, LCCS2 antibody, ErbB-3 antibody, c-erbB3 antibody, erbB3-S antibody, MDA-BF-1 antibody, c-erbB-3 antibody, p180-ErbB3 antibody, p45-sErbB3 antibody, p85-sErbB3 antibody
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SCBT cat No: sc-81454|sc-71067|sc-81455|sc-285|sc-292557|sc-415|sc-53279|sc-71071|

Name

Rabbit polyclonal ERBB3 antibody

Catalogue No.

A0950

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ERBB3

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 148kDa/Observed: Refer to Figures

Formulation

ERBB3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ERBB3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HER3 antibody, LCCS2 antibody, ErbB-3 antibody, c-erbB3 antibody, erbB3-S antibody, MDA-BF-1 antibody, c-erbB-3 antibody, p180-ErbB3 antibody, p45-sErbB3 antibody, p85-sErbB3 antibody

Database links

Human UniProt/Swiss-Prot:P21860

Protein names

HER3, LCCS2, ErbB-3, c-erbB3, erbB3-S, MDA-BF-1, c-erbB-3, p180-ErbB3, p45-sErbB3, p85-sErbB3

Protein function

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase . May also be activated by CSPG5 .

Protein tissue specificity

Epithelial tissues and brain.

Protein sequence and domain

The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.; Contains 1 protein kinase domain.

Protein post-translational modifications

Autophosphorylated . Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase .

Protein cellular localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.

Background

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Research area

All research areas>Membrane Receptors>ErbB
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize ERBB3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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