Rabbit polyclonal ERCC1 antibody (A5291)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ERCC1 antibody (A5291)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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UV20 antibody, COFS4 antibody, RAD10 antibody
COFS 4 antibody|COFS4 antibody|DNA excision repair protein ERCC 1 antibody|DNA excision repair protein ERCC-1 antibody|DNA excision repair protein ERCC1 antibody|ERCC 1 antibody|ERCC1 antibody|ERCC1_HUMAN antibody|Excision repair cross complementation group 1 antibody|Excision repair cross complementing 1 antibody|Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1 antibody|Excision repair protein antibody|RAD 10 antibody|RAD10 antibody|UV 20 antibody|UV20 antibody|Anti-ERCC1 antibody [8F1] (ab2356)

SCBT cat No: sc-53281|sc-56673|sc-515258|sc-17809|sc-10157|sc-10785|sc-56386|

Name

Rabbit polyclonal ERCC1 antibody

Catalogue No.

A5291

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ERCC1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 33kDa/Observed: Refer to Figures

Formulation

ERCC1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ERCC1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

UV20 antibody, COFS4 antibody, RAD10 antibody

Database links

Human UniProt/Swiss-Prot:P07992

Protein names

UV20, COFS4, RAD10

Protein function

Isoform 1: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5′-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.

Protein sequence and domain

Belongs to the ERCC1/RAD10/SWI10 family.

Protein cellular localization

Isoform 1: Nucleus.; Isoform 2: Cytoplasm. Nucleus.; Isoform 3: Nucleus.; Isoform 4: Nucleus.

Background

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5′ incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

Research area

All research areas>Transcription Regulators>ERCC1
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize ERCC1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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