Rabbit Polyclonal ERK 1 antibody (STJ92987)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal ERK 1 antibody (STJ92987)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:40000;

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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MAPK3 antibody, ERK1 antibody, PRKM3 antibody,|ERK 1 antibody|Extracellular signal-regulated kinase 2 antibody|HS44KDAP antibody|HUMKER1A antibody|Insulin stimulated MAP2 kinase antibody|MAP kinase 1 antibody|MAP kinase 2 antibody|MAP kinase 3 antibody|MAP kinase isoform p42 antibody|MAP kinase isoform p44 antibody|MAPK 1 antibody|MAPK 2 antibody|Mapk1 antibody|MAPK2 antibody|MAPK3 antibody|Microtubule associated protein 2 kinase antibody|Mitogen activated protein kinase 3 antibody|Mitogen-activated protein kinase 1 antibody|Mitogen-activated protein kinase 2 antibody|MK01_HUMAN antibody|p38 antibody|p40 antibody|p41 antibody|p41mapk antibody|p42-MAPK antibody|P42MAPK antibody|p44 ERK1 antibody|p44 MAPK antibody|P44ERK1 antibody|P44MAPK antibody|PRKM1 antibody|PRKM2 antibody|PRKM3 antibody|Protein tyrosine kinase ERK2 antibody|Anti-ERK1 + ERK2 antibody (ab17942)
SCBT cat No: sc-81457|sc-136288|sc-65981|sc-81458|sc-81459|sc-154|sc-271458|sc-1647|sc-271451|sc-153|sc-365234|sc-155|sc-374239|

 

Name

ERK 1 Polyclonal Antibody

Catalogue No.

STJ92987

Reactivity

Human, Mouse, Rat

Specificity

ERK 1 Polyclonal Antibody detects endogenous levels of ERK 1 protein.

Immunogen

Synthesized peptide derived from ERK 1 at AA range 130-210

Host

Rabbit

Applications

WB, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:40000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

44 kDa

Formulation

ERK 1 Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

ERK 1 Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Mitogen-activated protein kinase 3 antibody, MAP kinase 3 antibody, MAPK 3 antibody, ERT2 antibody, Extracellular signal-regulated kinase 1 antibody, ERK-1 antibody, Insulin-stimulated MAP2 kinase antibody, MAP kinase isoform p44 antibody, p44-MAPK antibody, Microtubule-associated protein 2 kinase antibody, p44-ERK1 antibody

Database links

Human UniProt/Swiss-Prot:P27361;Mouse UniPort/Swiss-Prot: Q63844;Rat UniProt/Swiss-Port: P21708;Human Entrez Gene: 5595;Mouse Entrez Gene: 26417;Rat Entrez Gene: Rn.2592

Protein names

Mitogen-activated protein kinase 3 , MAP kinase 3 , MAPK 3 , ERT2 , Extracellular signal-regulated kinase 1 , ERK-1 , Insulin-stimulated MAP2 kinase , MAP kinase isoform p44 , p44-MAPK , Microtubule-associated protein 2 kinase , p44-ERK1

Protein function

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. / ATP + a protein = ADP + a phosphoprotein. / Mg2+ / Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-202 and Tyr-204 in response to external stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Dephosphorylated and inactivated by DUSP3, DUSP6 and DUSP9.

Protein sequence and domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. / Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. / Contains 1 protein kinase domain.

Protein post-translational modifications

Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-204.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Kinases and Phosphatases>ERK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize ERK 1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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