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Rabbit polyclonal ERVFRD-1 antibody (A10162)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:1000 – 1:4000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal ERVFRD-1 antibody.
Check alternative names for the antibodyExpand
Endogenous retrovirus group W member 1 antibody|ENV antibody|Envelope polyprotein gPr73 antibody|Enverin antibody|ENVW antibody|ERVWE1 antibody|HERV-7q antibody|HERV-7q Envelope protein antibody|HERV-W envelope protein antibody|HERV-W-ENV antibody|HERV-W_7q21.2 provirus ancestral Env polyprotein antibody|HERV7Q antibody|HERVW antibody|HERVWENV antibody|Syncytin 1 antibody|Syncytin antibody|Syncytin1 antibody|Anti-HERV antibody (ab71115)
SCBT cat No: sc-164284|
Rabbit polyclonal ERVFRD-1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human ERVFRD-1
|Recommended dilution|| |
WB 1:1000 – 1:4000
|Molecular weight|| |
Predicted: 60kDa/Observed: Refer to figures
ERVFRD-1 antibody was tube-contained.
ERVFRD-1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process .; Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane .
|Protein tissue specificity|| |
Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea.
|Protein sequence and domain|| |
Contains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo (By similarity).Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily.
|Protein post-translational modifications|| |
Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.; The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion (By similarity).
|Protein cellular localization|| |
Virion .; Transmembrane protein: Cell membrane ; Single-pass membrane protein .
AntibodyPlus can customize ERVFRD-1 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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