Rabbit polyclonal ERVFRD-1 antibody (A10162)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal ERVFRD-1 antibody (A10162)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:1000 – 1:4000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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Endogenous retrovirus group W member 1 antibody|ENV antibody|Envelope polyprotein gPr73 antibody|Enverin antibody|ENVW antibody|ERVWE1 antibody|HERV-7q antibody|HERV-7q Envelope protein antibody|HERV-W envelope protein antibody|HERV-W-ENV antibody|HERV-W_7q21.2 provirus ancestral Env polyprotein antibody|HERV7Q antibody|HERVW antibody|HERVWENV antibody|Syncytin 1 antibody|Syncytin antibody|Syncytin1 antibody|Anti-HERV antibody (ab71115)

SCBT cat No: sc-164284|

Name

Rabbit polyclonal ERVFRD-1 antibody

Catalogue No.

A10162

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ERVFRD-1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:1000 – 1:4000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 60kDa/Observed: Refer to figures

Formulation

ERVFRD-1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ERVFRD-1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:P60508

Protein function

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process .; Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane .

Protein tissue specificity

Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea.

Protein sequence and domain

Contains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo (By similarity).Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily.

Protein post-translational modifications

Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.; The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion (By similarity).

Protein cellular localization

Virion .; Transmembrane protein: Cell membrane ; Single-pass membrane protein .

Note

AntibodyPlus can customize ERVFRD-1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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