Rabbit polyclonal ESR2 antibody (A2546)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal ESR2 antibody (A2546)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal ESR2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

Erb antibody, ESRB antibody, ESTRB antibody, NR3A2 antibody, ER-BETA antibody, ESR-BETA antibody
Atherosclerosis, susceptibility to, included antibody|DKFZp686N23123 antibody|ER Alpha antibody|ER antibody|ER Beta antibody|ER-alpha antibody|ER[a] antibody|ER[b] antibody|Era antibody|ERalpha antibody|Erb antibody|Erb2 antibody|ERbeta antibody|ESR antibody|ESR BETA antibody|ESR1 antibody|ESR1_HUMAN antibody|ESR2 antibody|ESRA antibody|ESRB antibody|Estr antibody|Estra antibody|Estradiol Receptor alpha antibody|Estradiol receptor antibody|Estradiol Receptor beta antibody|ESTRB antibody|Estrogen receptor 1 (alpha) antibody|Estrogen Receptor 1 antibody|Estrogen receptor 2 (ER beta) antibody|Estrogen Receptor 2 antibody|Estrogen receptor 2 ER beta antibody|Estrogen receptor alpha antibody|Estrogen receptor antibody|Estrogen receptor beta 4 antibody|Estrogen resistance, included antibody|HDL cholesterol, augmented response of, to hormone replacement, included antibody|Myocardial infarction, susceptibility to, included antibody|NR3A1 antibody|NR3A2 antibody|Nuclear receptor subfamily 3 group A member 1 antibody|Nuclear receptor subfamily 3 group A member 2 antibody|OTTHUMP00000017718 antibody|OTTHUMP00000017719 antibody|RNESTROR antibody|Anti-Estrogen Receptor antibody (ab53572)

SCBT cat No: sc-53494|sc-390243|sc-373853|sc-8974|sc-6822|sc-6820|sc-6821|

Name

Rabbit polyclonal ESR2 antibody

Catalogue No.

A2546

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human ESR2

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 59kDa/Observed: Refer to Figures

Formulation

ESR2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

ESR2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

Erb antibody, ESRB antibody, ESTRB antibody, NR3A2 antibody, ER-BETA antibody, ESR-BETA antibody

Database links

Human UniProt/Swiss-Prot:Q92731

Protein names

Erb, ESRB, ESTRB, NR3A2, ER-BETA, ESR-BETA

Protein function

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner . Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

Protein tissue specificity

Isoform 1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform 2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform 4 is found in testis. Isoform 5 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform 6 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.

Protein sequence and domain

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.Belongs to the nuclear hormone receptor family. NR3 subfamily.; Contains 1 nuclear receptor DNA-binding domain.

Protein post-translational modifications

Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.

Protein cellular localization

Nucleus .

Background

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

Research area

All research areas>Steroid Receptors>Estrogen Receptor
(View all antibody categories related to Steroid Receptors)

Note

AntibodyPlus can customize ESR2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!