Rabbit Polyclonal EXOSC1 antibody (A10302)

$99.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal EXOSC1 antibody (A10302)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

p13 antibody; CSL4 antibody; SKI4 antibody; Csl4p antibody; Ski4p antibody; CGI-108 antibody;
3′-5′ exoribonuclease CSL4 homolog antibody|CGI 108 antibody|CGI-108 antibody|CSL4 antibody|CSL4 exosomal core protein homolog antibody|CSL4, S. cerevisiae, homolog of antibody|Csl4p antibody|EXOS1_HUMAN antibody|Exosc1 antibody|Exosomal core protein CSL4 antibody|Exosome complex component csl4 antibody|Exosome component 1 antibody|hCsl4p antibody|Homolog of yeast exosomal core protein CSL4 antibody|p13 antibody|RP11-452K12.9 antibody|SKI4 antibody|Ski4p antibody|Anti-EXOSC1 antibody [EPR13526] (ab181108)

SCBT cat No:

Name

Rabbit Polyclonal EXOSC1 antibody

Catalogue No.

A10302

Reactivity

Human

Immunogen

Recombinant protein of human EXOSC1

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

21kDa

Formulation

EXOSC1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

p13 antibody; CSL4 antibody; SKI4 antibody; Csl4p antibody; Ski4p antibody; CGI-108 antibody;

Protein names

p13; CSL4; SKI4; Csl4p; Ski4p; CGI-108;

Protein function

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.

Protein sequence and domain

Belongs to the CSL4 family.; Contains 1 S1 motif domain.

Protein cellular localization

Nucleus, nucleolus . Nucleus . Cytoplasm .

Background

This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. Alternative splicing of this gene results in multiple transcript variants.

Note

AntibodyPlus can customize EXOSC1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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