Rabbit Polyclonal EXOSC2 antibody (A10450)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal EXOSC2 antibody (A10450)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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p7 antibody; RRP4 antibody; Rrp4p antibody; hRrp4p antibody;
EXOSC2 antibody|Exosome complex exonuclease RRP4 antibody|Exosome component 2 antibody|Homolog of yeast RRP4 (ribosomal RNA processing 4), 3′ 5′ exoribonuclease (RRP4) antibody|Homolog of yeast RRP4 (ribosomal RNA processing 4), 3′-5′-exoribonuclease antibody|hRrp4p antibody|OTTHUMP00000022370 antibody|OTTHUMP00000022371 antibody|OTTHUMP00000022372 antibody|OTTHUMP00000022373 antibody|OTTHUMP00000022374 antibody|p7 antibody|Ribosomal RNA processing protein 4 antibody|RRP4 antibody|Rrp4p antibody|Anti-RRP4 antibody [EPR13606(B)] – C-terminal (ab185235)

SCBT cat No: sc-81085|sc-104919|

Name

Rabbit Polyclonal EXOSC2 antibody

Catalogue No.

A10450

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human EXOSC2

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

32kDa

Formulation

EXOSC2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

p7 antibody; RRP4 antibody; Rrp4p antibody; hRrp4p antibody;

Protein names

p7; RRP4; Rrp4p; hRrp4p;

Protein function

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.

Protein sequence and domain

Belongs to the RRP4 family.; Contains 1 S1 motif domain.

Protein cellular localization

Cytoplasm. Nucleus, nucleolus. Nucleus.

Note

AntibodyPlus can customize EXOSC2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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