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Rabbit polyclonal EXT1 antibody (A2030)
$69.00–$259.00
Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.
Rabbit polyclonal EXT1 antibody (A2030)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
Recommended dilution:
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100
Recommended protocols: check protocols
Image descriptions:
Click or hover above images to see image description for Rabbit polyclonal EXT1 antibody.
Alternative names:
Check alternative names for the antibody
ExpandEXT antibody, LGS antibody, TTV antibody, LGCR antibody, TRPS2 antibody
4-alpha-N-acetylglucosaminyltransferase antibody|exostoses (multiple) 1 antibody|Exostosin 1 antibody|Exostosin glycosyltransferase 1 antibody|Exostosin-1 antibody|EXT antibody|EXT1 antibody|EXT1_HUMAN antibody|Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase antibody|glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan antibody|Langer-Giedion syndrome chromosome region antibody|LGCR antibody|LGS antibody|Multiple exostoses protein 1 antibody|Multiple exostoses protein 1 homolog antibody|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase antibody|Putative tumor suppressor protein EXT1 antibody|TRPS2 antibody|TTV antibody|Anti-Ext1 antibody (ab126305)
SCBT cat No: sc-515144|sc-292430|sc-11039|
Name | Rabbit polyclonal EXT1 antibody |
---|---|
Catalogue No. | A2030 |
Reactivity | Human, Mouse, Rat |
Immunogen | Recombinant protein of human EXT1 |
Host | Rabbit |
Applications | WB, IHC, IF |
Recommended dilution | WB 1:500 – 1:2000 |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Molecular weight | Predicted: 86kDa/Observed: Refer to Figures |
Formulation | EXT1 antibody was tube-contained. |
Purification | EXT1 antibody was purified using affinity purification. |
Storage | Store at -20 Celsius degree. Avoid freeze / thaw cycles. |
Alternative antibody names | EXT antibody, LGS antibody, TTV antibody, LGCR antibody, TRPS2 antibody |
Database links | Human UniProt/Swiss-Prot:Q16394 |
Protein names | EXT, LGS, TTV, LGCR, TRPS2 |
Protein function | Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan . |
Protein tissue specificity | Ubiquitous. |
Protein sequence and domain | Belongs to the glycosyltransferase 47 family. |
Protein cellular localization | Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein . Note: The EXT1/EXT2 complex is localized in the Golgi apparatus. |
Background | Hereditary multiple exostoses (EXT) is an autosomal dominant disorder characterized by the formation of cartilage-capped tumors (exostoses) that develop from the growth plate of endochondral bone. This condition can lead to skeletal abnormalities, short stature and malignant transformation of exostoses to chondrosarcomas or osteosarcomas. Linkage analyses have identified three different genes for EXT, EXT1 on 8q24.1, EXT2 on 11p11-13 and EXT3 on 19p, a family of tumor suppressor genes. Most EXT cases have been attributed to missense or frameshift mutations, which lead to loss of function of the EXT genes. EXT1 is an ER-resident type II transmembrane glycoprotein and a heparan sulphate polymerase with both D-glucuronyl and N-acetyl-D-glucosaminoglycan transferase activities. Expression of EXT1 in cells results in the alteration of the synthesis and display of cell surface heparan sulfate glycosaminoglycans. EXT1 mutations have been identified in multiple types of human tumors. |
Note | AntibodyPlus can customize EXT1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation. |
Product type | Primary antibody |
Supplier | ABclonal Inc. |
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