Rabbit polyclonal F11R antibody (A1241)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal F11R antibody (A1241)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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F11R antibody,CD321 antibody,JAM antibody,JAM-1 antibody,JAM-A antibody,JAM1 antibody,JAMA antibody,JCAM antibody,KAT antibody,PAM-1 antibody
CD 321 antibody|CD321 antibody|CD321 antigen antibody|ESTM33 antibody|F11 receptor antibody|F11R antibody|JAM 1 antibody|JAM A antibody|JAM antibody|JAM-1 antibody|JAM-A antibody|JAM1 antibody|JAM1_HUMAN antibody|JAMA antibody|JCAM antibody|Jcam1 antibody|Junction adhesion molecule 1 antibody|Junction adhesion molecule, mouse, homolog of antibody|Junctional adhesion molecule 1 antibody|Junctional adhesion molecule A antibody|KAT antibody|Ly106 antibody|PAM 1 antibody|PAM-1 antibody|PAM1 antibody|Platelet adhesion molecule 1 antibody|Platelet adhesion molecule antibody|Platelet F11 receptor antibody|PRO301 antibody|UNQ264 antibody|Anti-Junctional Adhesion Molecule 1 antibody [EP1042Y] (ab52647)

SCBT cat No: sc-52688|sc-17427|

Name

Rabbit polyclonal F11R antibody

Catalogue No.

A1241

Reactivity

Human

Immunogen

Recombinant protein of human F11R

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 33kDa/Observed: Refer to Figures

Formulation

F11R antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

F11R antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

F11R antibody,CD321 antibody,JAM antibody,JAM-1 antibody,JAM-A antibody,JAM1 antibody,JAMA antibody,JCAM antibody,KAT antibody,PAM-1 antibody

Database links

Human UniProt/Swiss-Prot:Q9Y624

Protein names

F11R,CD321,JAM,JAM-1,JAM-A,JAM1,JAMA,JCAM,KAT,PAM-1

Protein function

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 . The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration . Involved in platelet activation .; (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.; (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.

Protein tissue specificity

Expressed in endothelium, epithelium and leukocytes (at protein level).

Protein sequence and domain

The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2.Belongs to the immunoglobulin superfamily.; Contains 2 Ig-like V-type (immunoglobulin-like) domains.

Protein post-translational modifications

N-glycosylated.

Protein cellular localization

Cell junction, tight junction . Cell membrane ; Single-pass type I membrane protein . Note: Localized at tight junctions of both epithelial and endothelial cells.

Background

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5′ alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

Research area

All research areas>Cell Adhesion Proteins>JAM
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize F11R antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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