Rabbit polyclonal FAAH antibody (A1174)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FAAH antibody (A1174)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

FAAH antibody,FAAH1 antibody,MGC102823 antibody,MGC138146 antibody
Anandamide amidohydrolase 1 antibody|Anandamide amidohydrolase antibody|FA2H antibody|FAAH antibody|FAAH-1 antibody|FAAH1_HUMAN antibody|Fatty acid 2-hydroxylase antibody|Fatty acid alpha-hydroxylase antibody|Fatty acid amide hydrolase antibody|Fatty-acid amide hydrolase 1 antibody|MGC102823 antibody|MGC138146 antibody|Oleamide hydrolase 1 antibody|Oleamide hydrolase antibody|Anti-FAAH1 antibody (ab54615)

SCBT cat No: sc-100739|sc-26428|sc-366008|sc-26427|

Name

Rabbit polyclonal FAAH antibody

Catalogue No.

A1174

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FAAH

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 63kDa/Observed: Refer to Figures

Formulation

FAAH antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FAAH antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FAAH antibody,FAAH1 antibody,MGC102823 antibody,MGC138146 antibody

Database links

Human UniProt/Swiss-Prot:O00519

Protein names

FAAH,FAAH1,MGC102823,MGC138146

Protein function

Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

Protein tissue specificity

Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate.

Protein sequence and domain

Belongs to the amidase family.

Protein cellular localization

Endomembrane system ; Single-pass membrane protein . Cytoplasm, cytoskeleton . Note: Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.

Background

Endogenous cannabinoids have been implicated in addictive behaviors and drug abuse (1). Fatty-acid amide hydrolase 1 (FAAH1) is a plasma membrane-bound hydrolase that converts oleamide to oleic acid (2). This hydrolase also converts the cannabinoid anandamide, the endogenous ligand for the CB1 cannabinoid receptor, to arachidonic acid, suggesting a role in fatty-acid amide inactivation (2). Mice lacking FAAH1 have significantly higher levels of anandamide in the brain and show decreased sensitivity to pain, further indicating a role for FAAH1 in the regulation of endocannabinoid signaling in vivo (3). FAAH1 null mice also demonstrate an increased preference for alcohol and an increased voluntary uptake of alcohol as compared to wild-type mice, indicating a role of FAAH1 in modulating addictive behaviors (1).

Note

AntibodyPlus can customize FAAH antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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