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Rabbit polyclonal FADD antibody (A5819)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal FADD antibody.
Check alternative names for the antibodyExpand
GIG3 antibody, MORT1 antibody
FADD antibody|FADD protein antibody|FADD_HUMAN antibody|Fas (TNFRSF6) associated via death domain antibody|Fas associated via death domain antibody|Fas associating death domain containing protein antibody|Fas associating protein antibody|Fas associating protein with death domain antibody|Fas TNFRSF6 associated via death domain antibody|FAS-associated death domain protein antibody|FAS-associating death domain-containing protein antibody|GIG 3 antibody|GIG3 antibody|Growth inhibiting gene 3 protein antibody|Growth-inhibiting gene 3 protein antibody|H sapiens mRNA for mediator of receptor induced toxicity antibody|Mediator of receptor induced toxicity antibody|MGC8528 antibody|MORT 1 antibody|MORT1 antibody|Protein FADD antibody|Anti-FADD antibody (ab24533)
SCBT cat No: sc-271748|sc-134337|sc-292676|
Rabbit polyclonal FADD antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human FADD
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 23kDa/Observed: Refer to Figures
FADD antibody was tube-contained.
FADD antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
GIG3 antibody, MORT1 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
|Protein tissue specificity|| |
Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
|Protein sequence and domain|| |
Contains a death domain involved in the binding of the corresponding domain within Fas receptor.; The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing signaling complex (DISC).Contains 1 death domain.; Contains 1 DED (death effector) domain.
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
AntibodyPlus can customize FADD antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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