Rabbit polyclonal FADD antibody (A5819)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FADD antibody (A5819)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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GIG3 antibody, MORT1 antibody
FADD antibody|FADD protein antibody|FADD_HUMAN antibody|Fas (TNFRSF6) associated via death domain antibody|Fas associated via death domain antibody|Fas associating death domain containing protein antibody|Fas associating protein antibody|Fas associating protein with death domain antibody|Fas TNFRSF6 associated via death domain antibody|FAS-associated death domain protein antibody|FAS-associating death domain-containing protein antibody|GIG 3 antibody|GIG3 antibody|Growth inhibiting gene 3 protein antibody|Growth-inhibiting gene 3 protein antibody|H sapiens mRNA for mediator of receptor induced toxicity antibody|Mediator of receptor induced toxicity antibody|MGC8528 antibody|MORT 1 antibody|MORT1 antibody|Protein FADD antibody|Anti-FADD antibody (ab24533)

SCBT cat No: sc-271748|sc-134337|sc-292676|

Name

Rabbit polyclonal FADD antibody

Catalogue No.

A5819

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FADD

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 23kDa/Observed: Refer to Figures

Formulation

FADD antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FADD antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GIG3 antibody, MORT1 antibody

Database links

Human UniProt/Swiss-Prot:Q13158

Protein names

GIG3, MORT1

Protein function

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

Protein tissue specificity

Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.

Protein sequence and domain

Contains a death domain involved in the binding of the corresponding domain within Fas receptor.; The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing signaling complex (DISC).Contains 1 death domain.; Contains 1 DED (death effector) domain.

Background

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Research area

All research areas>Tumor Suppressor/Apoptosis>FADD
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize FADD antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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