Rabbit polyclonal FAIM3 antibody (A6320)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FAIM3 antibody (A6320)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

FCMR antibody, TOSO antibody
Faim3 antibody|FAIM3_HUMAN antibody|Fas apoptotic inhibitory molecule 3 antibody|Fc fragment of IgM receptor antibody|Fc mu receptor antibody|FCMR antibody|IgM Fc receptor antibody|Immunoglobulin mu Fc receptor antibody|Regulator of Fas induced apoptosis antibody|Regulator of Fas-induced apoptosis Toso antibody|TOSO antibody|Anti-FAIM3 antibody (ab56487)

SCBT cat No:

Name

Rabbit polyclonal FAIM3 antibody

Catalogue No.

A6320

Reactivity

Human

Immunogen

Recombinant protein of human FAIM3

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 43kDa/Observed: Refer to Figures

Formulation

FAIM3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FAIM3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FCMR antibody, TOSO antibody

Database links

Human UniProt/Swiss-Prot:O60667

Protein names

FCMR, TOSO

Protein function

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

Protein tissue specificity

Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells.

Protein sequence and domain

The Ig-like domain is required for the anti-apoptotic ability.Contains 1 Ig-like (immunoglobulin-like) domain.

Protein cellular localization

Isoform 1: Membrane ; Single-pass membrane protein .; Isoform 3: Secreted . Note: Detected in the serum.

Background

Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009

Note

AntibodyPlus can customize FAIM3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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