Rabbit polyclonal FASN antibody (A0461)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FASN antibody (A0461)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal FASN antibody.

Alternative names:

Check alternative names for the antibody

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FASN antibody,FAS antibody,MGC14367 antibody,MGC15706 antibody,OA-519 antibody,SDR27X1 antibody
[Acyl-carrier-protein] S acetyltransferase antibody|[Acyl-carrier-protein] S malonyltransferase antibody|3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase antibody|3-oxoacyl-[acyl-carrier-protein] reductase antibody|3-oxoacyl-[acyl-carrier-protein] synthase antibody|Enoyl-[acyl-carrier-protein] reductase antibody|FAS antibody|FAS_HUMAN antibody|FASN antibody|Fatty acid synthase antibody|MGC14367 antibody|MGC15706 antibody|OA 519 antibody|Oleoyl-[acyl-carrier-protein] hydrolase antibody|SDR27X1 antibody|Short chain dehydrogenase/reductase family 27X member 1 antibody|Anti-Fatty Acid Synthase antibody (ab22759)

SCBT cat No: sc-55580|sc-16147|sc-48357|sc-20140|

Name

Rabbit polyclonal FASN antibody

Catalogue No.

A0461

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FASN

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 272kDa/Observed: Refer to Figures

Formulation

FASN antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FASN antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FASN antibody,FAS antibody,MGC14367 antibody,MGC15706 antibody,OA-519 antibody,SDR27X1 antibody

Database links

Human UniProt/Swiss-Prot:P49327

Protein names

FASN,FAS,MGC14367,MGC15706,OA-519,SDR27X1

Protein function

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.

Protein tissue specificity

Ubiquitous. Prominent expression in brain, lung, and liver.

Protein sequence and domain

Contains 1 acyl carrier domain.

Protein cellular localization

Cytoplasm . Melanosome . Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Background

Fatty acid synthase (FASN) catalyzes the synthesis of long-chain fatty acids from acetyl-CoA and malonyl-CoA. FASN is active as a homodimer with seven different catalytic activities and produces lipids in the liver for export to metabolically active tissues or storage in adipose tissue. In most other human tissues, FASN is minimally expressed since they rely on circulating fatty acids for new structural lipid synthesis (1).Recently, increased expression of FASN has emerged as a phenotype common to most human carcinomas. In breast cancer, immunohistochemical staining showed that the levels of FASN are directly related to the size of breast tumors (2). Studies also showed that FASN is highly expressed in lung and prostate cancers and that FASN expression is an indicator of poor prognosis in breast and prostate cancer (3-5). Furthermore, inhibition of FASN is selectively cytotoxic to human cancer cells (5). Thus, increased interest has focused on FASN as a potential target for the diagnosis and treatment of cancer as well as metabolic syndrome (6,7).

Research area

All research areas>Synthesis and Degradation>Fatty Acid
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize FASN antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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