Rabbit polyclonal FBL antibody (A1136)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP,RIP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FBL antibody (A1136)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF,IP,RIP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200 IP 1:20 – 1:50 RIP 1:20 – 1:50

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

FBL antibody,FIB antibody,FLRN antibody,RNU3IP1 antibody
34 kD nucleolar scleroderma antigen antibody|34 kDa nucleolar scleroderma antigen antibody|Fbl antibody|FBRL_HUMAN antibody|FIB antibody|FIB1 antibody|FLRN antibody|Histone-glutamine methyltransferase antibody|Nop1p antibody|RNA U3 small nucleolar interacting protein 1 antibody|RNU3IP1 antibody|rRNA 2′ O methyltransferase fibrillarin antibody|rRNA 2′-O-methyltransferase fibrillarin antibody|Anti-Fibrillarin antibody [38F3] (ab4566)

SCBT cat No: sc-11335|sc-166001|sc-11336|sc-166000|sc-166021|sc-374022|sc-25397|sc-514239|

Name

Rabbit polyclonal FBL antibody

Catalogue No.

A1136

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FBL

Host

Rabbit

Applications

WB, IHC, IF, IP, RIP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200
IP 1:20 – 1:50
RIP 1:20 – 1:50

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 34kDa/Observed: Refer to Figures

Formulation

FBL antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FBL antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FBL antibody,FIB antibody,FLRN antibody,RNU3IP1 antibody

Database links

Human UniProt/Swiss-Prot:P22087

Protein names

FBL,FIB,FLRN,RNU3IP1

Protein function

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2′-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of ‘Gln-105’ of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus .

Protein sequence and domain

Belongs to the methyltransferase superfamily. Fibrillarin family.

Protein post-translational modifications

By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).

Protein cellular localization

Nucleus, nucleolus . Note: Fibrillar region of the nucleolus.

Background

Fibrillarin is a 2′-O-methyltransferase located in fibrillar regions and Cajal bodies of the nucleolus, where RNA transcription and pre-RNA processing take place (1,2). Fibrillarin associates with several other structual proteins as well as box C/D snoRNA to form a complex that functions in pre-rRNA processing, pre-rRNA methylation and ribosome assembly. This complex catalyzes site-specific 2′-O-ribose methylation of targeted nucleotides within the rRNA sequence (3,4). The sequence, structure and function of fibrillarin are highly conserved and fibrillarin gene expression is essential for early embryonic development (5).

Note

AntibodyPlus can customize FBL antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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