Rabbit polyclonal FBXL5 antibody (A5602)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FBXL5 antibody (A5602)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:1000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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FBXL5 antibody, FBL4 antibody, FBL5 antibody, FLR1 antibody, F-box/LRR-repeat protein 5 antibody
F box and leucine rich repeat protein 5 antibody|F box protein FBL5 antibody|F box/LRR repeat protein 5 antibody|F-box and leucine-rich repeat protein 5 antibody|F-box protein FBL4/FBL5 antibody|F-box/LRR-repeat protein 5 antibody|FBL4 antibody|FBL5 antibody|FBXL5 antibody|FBXL5_HUMAN antibody|FLR1 antibody|p45SKP2 like protein antibody|p45SKP2-like protein antibody|Anti-FBXL5 antibody (ab140175)

SCBT cat No: sc-390102|sc-134984|sc-54364|

Name

Rabbit polyclonal FBXL5 antibody

Catalogue No.

A5602

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FBXL5

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:1000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 79kDa/Observed: Refer to Figures

Formulation

FBXL5 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FBXL5 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FBXL5 antibody, FBL4 antibody, FBL5 antibody, FLR1 antibody, F-box/LRR-repeat protein 5 antibody

Database links

Human UniProt/Swiss-Prot:Q9UKA1

Protein names

FBXL5, FBL4, FBL5, FLR1, F-box/LRR-repeat protein 5

Protein function

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.

Protein sequence and domain

The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron metal-center. In absence of oxygen and iron, the protein is ubiquitinated and degraded.Contains 1 F-box domain.; Contains 7 LRR (leucine-rich) repeats.

Protein post-translational modifications

Polybiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor.

Protein cellular localization

Cytoplasm, perinuclear region .

Background

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus.

Note

AntibodyPlus can customize FBXL5 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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