Rabbit polyclonal FBXO22 antibody (A8367)

$69.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FBXO22 antibody (A8367)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal FBXO22 antibody.

Alternative names:

Check alternative names for the antibody

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FBX22 antibody, FISTC1 antibody
0610033L19Rik antibody|1600016C16Rik antibody|F box only protein 22 antibody|F box protein 22 antibody|F box protein FBX22p44 antibody|F-box only protein 22 antibody|F-box protein FBX22p44 antibody|FBX22 antibody|FBX22_HUMAN antibody|FBXO 22 antibody|FBXO22 antibody|FIST domain containing 1 antibody|FISTC1 antibody|FLJ13986 antibody|MGC124731 antibody|MGC31799 antibody|Anti-FBXO22 antibody (ab82974)

SCBT cat No: sc-100736|

Name

Rabbit polyclonal FBXO22 antibody

Catalogue No.

A8367

Reactivity

Human

Immunogen

Recombinant protein of human FBXO22

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 45kDa/Observed: Refer to figures

Formulation

FBXO22 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FBXO22 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FBX22 antibody, FISTC1 antibody

Database links

Human UniProt/Swiss-Prot:Q8NEZ5

Protein names

FBX22, FISTC1

Protein function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

Protein tissue specificity

Predominantly expressed in liver, also enriched in cardiac muscle.

Protein sequence and domain

Contains 1 F-box domain.

Protein cellular localization

Cytoplasm, myofibril, sarcomere, Z line .

Background

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants.

Research area

All research areas>Signaling Intermediates>FBXO
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize FBXO22 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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